mortality/aging
• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days
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hematopoietic system
N |
• no significant differences are observed in hematopoietic parameters like erthroid volume, bone marrow cellularity, red and white blood cell numbers, platelet or neutrophil numbers, or lymphocyte subset numbers
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• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls
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immune system
• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls
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homeostasis/metabolism
• after irradiation, increase in Kit ligand in serum of mutants (0.3 ng/ml to 0.7 ng/ml) is much less than in wild-type (0.3 ng/ml vs 2.2 ng/ml after irradiation)
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• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days
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