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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kitltm1Pbes
targeted mutation 1, Peter Besmer
MGI:3664559
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kitltm1Pbes/Kitltm1Pbes involves: 129S1/Sv * C57BL/6J MGI:3707164


Genotype
MGI:3707164
hm1
Allelic
Composition
Kitltm1Pbes/Kitltm1Pbes
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1Pbes mutation (0 available); any Kitl mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days

hematopoietic system
N
• no significant differences are observed in hematopoietic parameters like erthroid volume, bone marrow cellularity, red and white blood cell numbers, platelet or neutrophil numbers, or lymphocyte subset numbers
• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls

immune system
• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls

homeostasis/metabolism
• after irradiation, increase in Kit ligand in serum of mutants (0.3 ng/ml to 0.7 ng/ml) is much less than in wild-type (0.3 ng/ml vs 2.2 ng/ml after irradiation)
• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory