About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kitltm1Pbes
targeted mutation 1, Peter Besmer
MGI:3664559
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kitltm1Pbes/Kitltm1Pbes involves: 129S1/Sv * C57BL/6J MGI:3707164


Genotype
MGI:3707164
hm1
Allelic
Composition
Kitltm1Pbes/Kitltm1Pbes
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kitltm1Pbes mutation (0 available); any Kitl mutation (94 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days

hematopoietic system
N
• no significant differences are observed in hematopoietic parameters like erthroid volume, bone marrow cellularity, red and white blood cell numbers, platelet or neutrophil numbers, or lymphocyte subset numbers
• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls

immune system
• mast cell numbers in skin and peritoneal tissue are decreased compared to wild-type; skin at 15 weeks contains only 8% of that in control tissue, and peritoneal mast cell numbers is <2% of that in controls

homeostasis/metabolism
• after irradiation, increase in Kit ligand in serum of mutants (0.3 ng/ml to 0.7 ng/ml) is much less than in wild-type (0.3 ng/ml vs 2.2 ng/ml after irradiation)
• at a sublethal dose of 6.5 Gy, mutants display only 50-60% survival rate after 4 weeks, while controls show 95-100% survival; mortality onset is invariably between 12 and 20 days





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/19/2024
MGI 6.24
The Jackson Laboratory