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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mr1tm1Gfn
targeted mutation 1, Susan Gilfillan
MGI:3664578
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mr1tm1Gfn/Mr1tm1Gfn B6.129P2-Mr1tm1Gfn MGI:3814895
hm2
 		Mr1tm1Gfn/Mr1tm1Gfn involves: 129P2/OlaHsd MGI:6360155
hm3
 		Mr1tm1Gfn/Mr1tm1Gfn involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:3814822


Genotype
MGI:3814895
hm1
Allelic
Composition		 Mr1tm1Gfn/Mr1tm1Gfn
Genetic
Background		 B6.129P2-Mr1tm1Gfn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mr1tm1Gfn mutation (2 available); any Mr1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to experimental autoimmune encephalomyelitis ( J:112657 )
• mice have a significantly more severe form of EAE with an earlier onset than controls after induction with MOG peptide
• mean day of onset is 11.5 compared to 13.9 for wild-type controls
• mean severity score is 4.0 versus 3.0 in wild-type controls
• memory T cells isolated from mice 10 days after disease induction proliferate more and produce more TH-1 cytokines and less IL-10




Genotype
MGI:6360155
hm2
Allelic
Composition		 Mr1tm1Gfn/Mr1tm1Gfn
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mr1tm1Gfn mutation (2 available); any Mr1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal susceptibility to bacterial infection ( J:276912 )
• L. longbeachae-infected mice fail to exhibit an increase in atypical MR1 tetramer-reactive cells in the lungs compared with wild-type mice




Genotype
MGI:3814822
hm3
Allelic
Composition		 Mr1tm1Gfn/Mr1tm1Gfn
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mr1tm1Gfn mutation (2 available); any Mr1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell number ( J:113083 )
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
abnormal B cell physiology ( J:113083 )
• preliminary results indicate a reduction in the number of IgA producing B cells in the gut

hematopoietic system
abnormal T cell number ( J:113083 )
• mucosal-associated invariant T cells (MAIT) that express the canonical mVa19-Ja33 TCR rearrangement and are typically found in the gut lamina propia are virtually absent in these mice
abnormal B cell physiology ( J:113083 )
• preliminary results indicate a reduction in the number of IgA producing B cells in the gut




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory