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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dnai7Gt(VICTR21)709Lex
gene trap 709, Lexicon Genetics
MGI:3664581
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dnai7Gt(VICTR21)709Lex/Dnai7Gt(VICTR21)709Lex involves: 129S5/SvEvBrd MGI:3689217
ht2
 		Dnai7Gt(VICTR21)709Lex/Dnai7+ involves: 129S5/SvEvBrd MGI:3689220


Genotype
MGI:3689217
hm1
Allelic
Composition		 Dnai7Gt(VICTR21)709Lex/Dnai7Gt(VICTR21)709Lex
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnai7Gt(VICTR21)709Lex mutation (0 available); any Dnai7 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:111629 )
• 6X more tumors/mouse after treatment with urethane than seen in C57BL/6J (resistant) controls
increased lung adenocarcinoma incidence ( J:111629 )
• 29.1% of mice develop lung adenocarcenomas
• frequent invasion into bronchioles causing blockage

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:111629 )
• 6X more tumors/mouse after treatment with urethane than seen in C57BL/6J (resistant) controls

respiratory system
increased lung adenocarcinoma incidence ( J:111629 )
• 29.1% of mice develop lung adenocarcenomas
• frequent invasion into bronchioles causing blockage




Genotype
MGI:3689220
ht2
Allelic
Composition		 Dnai7Gt(VICTR21)709Lex/Dnai7+
Genetic
Background		 involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnai7Gt(VICTR21)709Lex mutation (0 available); any Dnai7 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:111629 )
• 3X more tumors/mouse after treatment with urethane than seen in C57BL/6J (resistant) controls
increased lung adenocarcinoma incidence ( J:111629 )
• 16.8% of mice develop lung adenocarcenomas

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:111629 )
• 3X more tumors/mouse after treatment with urethane than seen in C57BL/6J (resistant) controls

respiratory system
increased lung adenocarcinoma incidence ( J:111629 )
• 16.8% of mice develop lung adenocarcenomas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory