Phenotypes associated with this allele

• Allele Symbol: Mapk9^tm1.1Rjd
• Allele Name: targeted mutation 1.1, Roger J Davis
• Allele ID: MGI:3664582
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mapk8^tm1Flv/Mapk8^tm1Flv Mapk9^tm1.1Rjd/Mapk9^tm1.1Rjd	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:3707190

Genotype
MGI:3707190

cx1

• Allelic Composition: Mapk8^tm1Flv/Mapk8^tm1Flv; Mapk9^tm1.1Rjd/Mapk9^tm1.1Rjd
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased fibroblast apoptosis ( J:112737 )

• treatment of TNF or UV-stimulated MEFs with 1NM-PP1 increases TNF-induced apoptosis and decreases Uv-stimulated apoptosis while such treatment causes no change in wild-type or Mapk9^tm1Rjd MEFs

increased fibroblast cell migration ( J:112737 )

• a scratch wound in monolayers of wild-type MEFs is rapid, but is markedly slowed upon treatment with 1NM-PP1, compared to wild-type or or Mapk9^tm1Rjd MEFs

decreased keratinocyte migration ( J:112737 )

• keratinocytes in culture show slightly reduced motility compared to wild-type and treatment with 1NM-PP1 results in significantly decreased migration compared to treated or untreated wild-type MEFs

decreased fibroblast proliferation ( J:112737 )

• compared to wild-type, MEFs show reduced proliferation in culture; after treatment with a protein kinase inhibibitor (1NM-PP1), proliferation is reduced even more

integument

decreased keratinocyte migration ( J:112737 )

• keratinocytes in culture show slightly reduced motility compared to wild-type and treatment with 1NM-PP1 results in significantly decreased migration compared to treated or untreated wild-type MEFs