About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ms4a2tm1Knt
targeted mutation 1, Jean-Pierre Kinet
MGI:3664659
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ms4a2tm1Knt/Ms4a2tm1Knt involves: 129 * BALB/c MGI:3703596
cx2
 		Ms4a2tm1Knt/Ms4a2tm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0 		involves: 129 * BALB/c MGI:3703595


Genotype
MGI:3703596
hm1
Allelic
Composition		 Ms4a2tm1Knt/Ms4a2tm1Knt
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a2tm1Knt mutation (1 available); any Ms4a2 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:47138 )
• after stimulation with 2.4G2, very little bone marrow mast cell degranulation is observed
decreased susceptibility to type I hypersensitivity reaction ( J:47138 )
• injection of 2.4G2 to induce anaphylaxis results in a smaller decrease in rectal temperature ( 2 degrees) compared to Fcer1a-deficient mice (8 degrees) or wild-type mice (4 degrees)
abnormal cytokine secretion ( J:47138 )
• Il-6 production in stimulated BMMCs is reduced compared to Fcer1a-null mice

hematopoietic system
abnormal mast cell physiology ( J:47138 )
• after stimulation with 2.4G2, very little bone marrow mast cell degranulation is observed




Genotype
MGI:3703595
cx2
Allelic
Composition		 Ms4a2tm1Knt/Ms4a2tm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ms4a2tm1Knt mutation (1 available); any Ms4a2 mutation (12 available)
Tg(SV40/HTLV-FCER1A)1Bhk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:47138 )
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice
decreased susceptibility to type I hypersensitivity reaction ( J:47138 )
• mice show a weaker response (temperature drop) in a model of anaphlaxis (injections of IgE every 12 hours for 36 hours, then antigenic challenge)
abnormal cytokine secretion ( J:47138 )
• Il-6 production in stimulated BMMCs is reduced compared to Ms4a2-heterozygous transgenic mice

hematopoietic system
abnormal mast cell physiology ( J:47138 )
• degranulation of bone marrow mast cells (BMMC) induced by antigen-receptor bound IgE crosslinking is 3- to 5-fold reduced compared to those in Ms4a2-heterozygous transgenic mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory