Analysis Tools
mortality/aging
 |
• in mice where doxycycline treatment begins at 4 weeks of age most mice die between 5 to 6 weeks after initiation of treatment with none surviving more than 10 weeks
|
|
|
• mice exposed to doxycycline for 4 days beginning at E12.5 die within 1 day after birth probably as a result of hematopoietic failure
|
|
|
• treatment with doxycycline before E9.5 results in death of the embryo within 3 days
|
hematopoietic system
small thymus
(
J:112954
)
|
|
• 6 weeks after initiation of doxycycline treatment (started at 4 weeks of age)the thymus is severely reduced in size or absent
|
|
|
• all T cell subsets rapidly decline after initiation of doxycycline treatment (started at 4 weeks of age) producing a strong reduction in overall cellularity
|
|
|
• all T cell subsets rapidly decline in the thymus after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• doxycycline treatment initiated at 4 weeks of age results in rapid loss of lineage committed immature cells; however populations of progenitor cells that include hematopoietic stem cells and pre-pro B cells are expanded 20- and 10-fold, respectively, after 2 weeks of treatment
|
|
|
• a transient expansion of Ter119+ erythroid cells is seen 7 days after initiation of doxycycline treatment (started at 4 weeks of age); however erythroid progenitors are significantly reduced at the same time
|
|
|
• severely reduced in the bone marrow at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
• however, mature B cells in the bone marrow and spleen are only slightly affected at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• 2-fold reduction in the bone marrow at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• most rapidly lost of the all the T-cell subsets in the thymus after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• reduction in red cell markers indicates loss of red cells in neonates treated for 4 days with doxycycline beginning at E12.5
• seen 4 weeks after initiation of doxycycline treatment when treatment is started at 4 weeks of age
|
|
|
• seen 6 weeks after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• severe decrease in neonates treated for 4 days with doxycycline beginning at E12.5
• in mice where doxycycline treatment begins at 4 weeks of age hematocrit decreases to 1/10 of untreated controls
|
|
|
• doxycycline treatment-induced loss is more gradual than for macrophages but still significant
|
|
|
• nearly absent in the bone marrow at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• most rapidly lost cell type of the myeloid lineages after doxycycline treatment (started at 4 weeks of age)
|
embryo
|
|
• treatment with doxycycline at E9.5 results in a severely deformed embryo at E13.5
|
immune system
small thymus
(
J:112954
)
|
|
• 6 weeks after initiation of doxycycline treatment (started at 4 weeks of age)the thymus is severely reduced in size or absent
|
|
|
• all T cell subsets rapidly decline after initiation of doxycycline treatment (started at 4 weeks of age) producing a strong reduction in overall cellularity
|
|
|
• all T cell subsets rapidly decline in the thymus after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• severely reduced in the bone marrow at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
• however, mature B cells in the bone marrow and spleen are only slightly affected at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• 2-fold reduction in the bone marrow at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• most rapidly lost of the all the T-cell subsets in the thymus after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• doxycycline treatment-induced loss is more gradual than for macrophages but still significant
|
|
|
• nearly absent in the bone marrow at 5 and 7 days after initiation of doxycycline treatment (started at 4 weeks of age)
|
|
|
• most rapidly lost cell type of the myeloid lineages after doxycycline treatment (started at 4 weeks of age)
|
behavior/neurological
|
|
• 2 weeks after initiation of doxycycline treatment (started at 4 weeks of age) mice appear weak
|
endocrine/exocrine glands
small thymus
(
J:112954
)
|
|
• 6 weeks after initiation of doxycycline treatment (started at 4 weeks of age)the thymus is severely reduced in size or absent
|
|
|
• all T cell subsets rapidly decline after initiation of doxycycline treatment (started at 4 weeks of age) producing a strong reduction in overall cellularity
|
|
|
• all T cell subsets rapidly decline in the thymus after initiation of doxycycline treatment (started at 4 weeks of age)
|
