Analysis Tools
immune system
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• cultured BMMCs show reduced survival compared to wild-type cells, coincident with increased apoptosis
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• show reduced expression/production of proinflammatory mediators and cytokines upon IgE-activation
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• reduced expression of proinflammatory mediators and cytokines is observed in LPS-stimulated macrophages and IgE-activated bone marrow-derived mast cells (BMMCs) from in 8-12 week old mutant mice
• LPS-stimulated macrophages producing Il-12 are fewer in number, and produce less Il-12 than wild-type macrophages; prostagland-E2 and nitric oxide production by stimulated macrophages is lower than in wild-type
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• after injection of arthritogenic K/BxN mouse serum, mutants are protected, particularly during the first 5 days from development of peripheral inflammatory arthritis, in contrast to wild-type littermates which develop inflammatory arthritis within 2 days
• after 5 days, mice show greatly diminished clinical and histological features of arthritis
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skeleton
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• after injection of arthritogenic K/BxN mouse serum, mutants are protected, particularly during the first 5 days from development of peripheral inflammatory arthritis, in contrast to wild-type littermates which develop inflammatory arthritis within 2 days
• after 5 days, mice show greatly diminished clinical and histological features of arthritis
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hematopoietic system
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• cultured BMMCs show reduced survival compared to wild-type cells, coincident with increased apoptosis
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• show reduced expression/production of proinflammatory mediators and cytokines upon IgE-activation
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