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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdia3tm1Gjh
targeted mutation 1, Gunter J Hammerling
MGI:3664742
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Pdia3tm1Gjh/Pdia3tm1Gjh 		involves: 129P2/OlaHsd * C57BL/6 MGI:3702091


Genotype
MGI:3702091
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Pdia3tm1Gjh/Pdia3tm1Gjh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Pdia3tm1Gjh mutation (0 available); any Pdia3 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:112606 )
• naive B cells express 50% - 90% less H-2Kb and have decreased H-2Db expression
• however, B cell development, survival, and proliferative responses are similar to control mice and mice raise normal titers of IgG

hematopoietic system
abnormal B cell physiology ( J:112606 )
• naive B cells express 50% - 90% less H-2Kb and have decreased H-2Db expression
• however, B cell development, survival, and proliferative responses are similar to control mice and mice raise normal titers of IgG




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory