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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Myh10tm5Rsad
targeted mutation 5, Robert S Adelstein
MGI:3664765
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Myh10tm5Rsad/Myh10tm5Rsad involves: 129S6/SvEvTac * C57BL/6 MGI:3702178
ht2
 		Myh10tm2Rsad/Myh10tm5Rsad involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:3702182
cn3
 		Myh10tm5Rsad/Myh10tm5Rsad
Tg(CMV-cre)1Cgn/0 		involves: 129S6/SvEvTac * BALB/cJ * C57BL/6 MGI:3702183


Genotype
MGI:3702178
hm1
Allelic
Composition		 Myh10tm5Rsad/Myh10tm5Rsad
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10tm5Rsad mutation (0 available); any Myh10 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:112536 )
• mice show reduced ability to maintain balance on rotarod

nervous system
nervous system phenotype ( J:112536 )
N
• facial neuron migration is normal
abnormal cerebellar Purkinje cell layer ( J:112536 )
• small number of Purkinje cells have abnormal orientation deviating from normal orientation where cell bodies are perpendicular to the surface of the cerebellar cortex
abnormal Purkinje cell dendrite morphology ( J:112536 )
• almost all cells show a marked decrease in branches and dendritic spines compared to wild-type
ectopic Purkinje cell ( J:112536 )
• cell bodies of some Purkinje cells are dissociated from the cerebellar Purkinje cell layer and ectopically located in molecular layer




Genotype
MGI:3702182
ht2
Allelic
Composition		 Myh10tm2Rsad/Myh10tm5Rsad
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10tm2Rsad mutation (1 available); any Myh10 mutation (95 available)
Myh10tm5Rsad mutation (0 available); any Myh10 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
hydrocephaly ( J:112536 )
• mice show severe hydroencephaly
abnormal fourth ventricle morphology ( J:112536 )
• mice show protrusion of facial neurons into fourth ventricle




Genotype
MGI:3702183
cn3
Allelic
Composition		 Myh10tm5Rsad/Myh10tm5Rsad
Tg(CMV-cre)1Cgn/0
Genetic
Background		 involves: 129S6/SvEvTac * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10tm5Rsad mutation (0 available); any Myh10 mutation (95 available)
Tg(CMV-cre)1Cgn mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:112536 )
• mice show reduced ability to maintain balance on rotarod; performance depends on rate of rotation, such that at low speeds, mice show no deficiency

nervous system
abnormal cerebellar Purkinje cell layer ( J:112536 )
• small number of Purkinje cells have abnormal orientation deviating from normal orientation where cell bodies are perpendicular to the surface of the cerebellar cortex
abnormal Purkinje cell dendrite morphology ( J:112536 )
• almost all cells show a marked decrease in branches and dendritic spines compared to wild-type
ectopic Purkinje cell ( J:112536 )
• cell bodies of some Purkinje cells are dissociated from the cerebellar Purkinje cell layer and ectopically located in molecular layer




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory