Phenotypes associated with this allele

• Allele Symbol: Gas6^tm1Hiar
• Allele Name: targeted mutation 1, Hidenori Arai
• Allele ID: MGI:3664768
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gas6^tm1Hiar/Gas6^tm1Hiar	B6.129P2-Gas6^tm1Hiar	MGI:3702085

Genotype
MGI:3702085

hm1

• Allelic Composition: Gas6^tm1Hiar/Gas6^tm1Hiar
• Genetic Background: B6.129P2-Gas6^tm1Hiar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:112430 )

• all male mutants with induced nephrotoxic nephritis (NTN) survive until day 21 after induction; 37.5% of wild-type mice die between day 3 and 11 after NTN induction

• wild-type mice that died had blood in the urine in their bladders

renal/urinary system

decreased kidney cell proliferation ( J:112430 )

• mutants with NTN show much less proliferation in glomeruli than wild-type mice on day 7

albuminuria ( J:112430 )

• wild-type mice with NTN show increased urinary excretion of albumin on day 7 and peaking on day 14 whereas mutant males have significantly less proteinuria on those time points

abnormal renal glomerulus morphology ( J:112430 )

• glomerular cell number is lower in mutants with NTN on days 0, 7, 14, and 21 compared to wild-type mice with NTN, although significance is reached only on day 14

glomerulosclerosis ( J:112430 )

• 8-week old male mutants with induced nephtotoxic nephritis (NTN) show less glomerulosclerosis than wild-type controls (13% of mutants vs 47% of wild-type)

glomerular crescent ( J:112430 )

• 8-week old male mutants with induced nephtotoxic nephritis (NTN) show less crescent formation than wild-type controls (11% of mutants vs 30% of wild-type mice)

immune system

immune system phenotype ( J:112430 )

N • mutant mice with NTN show similar humoral immune response as diseased wild-type

N • immune response to sheep IgG is similar with similar glomerular deposition of sheep IgG and production of sheep IgG antibodies

homeostasis/metabolism

abnormal circulating serum albumin level ( J:112430 )

• male mutants with NTN show normal serum albumin level but wild-type mice with severe proteinuria show reduced serum albumin levels

albuminuria ( J:112430 )

• wild-type mice with NTN show increased urinary excretion of albumin on day 7 and peaking on day 14 whereas mutant males have significantly less proteinuria on those time points

cellular

decreased kidney cell proliferation ( J:112430 )

• mutants with NTN show much less proliferation in glomeruli than wild-type mice on day 7