Phenotypes associated with this allele

• Allele Symbol: Sfrp2^tm1Sato
• Allele Name: targeted mutation 1, Thomas N Sato
• Allele ID: MGI:3664776
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sfrp2^tm1Sato/Sfrp2^tm1Sato	Not Specified	MGI:3664780

Genotype
MGI:3664780

hm1

• Allelic Composition: Sfrp2^tm1Sato/Sfrp2^tm1Sato
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:112802 )

• expression analysis indicates disruption of the boundary between the progenitor regions for V3 and MN neurons in the ventral spinal cord with expansion of the area occupied by V3 progenitors

cardiovascular system

increased cardiac muscle contractility ( J:146963 )

• 14 days following coronary artery ligation, mice retain pre-operation ejection fraction (EF) compared to similarly treated wild-type mice that experience a drop in EF

abnormal response of heart to induced stress ( J:146963 )

• following coronary artery ligation, mice exhibit reduced fibrosis and improved heart function compared to similarly treated wild-type mice

homeostasis/metabolism

abnormal response of heart to induced stress ( J:146963 )

• following coronary artery ligation, mice exhibit reduced fibrosis and improved heart function compared to similarly treated wild-type mice

muscle

increased cardiac muscle contractility ( J:146963 )

• 14 days following coronary artery ligation, mice retain pre-operation ejection fraction (EF) compared to similarly treated wild-type mice that experience a drop in EF

cellular

abnormal neuron differentiation ( J:112802 )

• expression analysis indicates disruption of the boundary between the progenitor regions for V3 and MN neurons in the ventral spinal cord with expansion of the area occupied by V3 progenitors