Phenotypes associated with this allele

• Allele Symbol: Myo1f^tm1.1Flv
• Allele Name: targeted mutation 1.1, Richard A Flavell
• Allele ID: MGI:3664779
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo1f^tm1.1Flv/Myo1f^tm1.1Flv	involves: 129S6/SvEvTac	MGI:3702079

Genotype
MGI:3702079

hm1

• Allelic Composition: Myo1f^tm1.1Flv/Myo1f^tm1.1Flv
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired neutrophil chemotaxis ( J:113020 )

• deficient neutrophils show increased spreading on ICAM-1 compared to wild-type cells

• in culture, neutrophil migration is severely impaired on fibronectin

• when mutant neutrophils are transferred to Listeria monocytogenes-infected mice, neutrophils are found in lower numbers in recipient livers, suggesting compromised mobilization in mutant cells

cellular

abnormal cell adhesion ( J:113020 )

• cultured neutrophils show increased adhesion to integrin ligands (ICAM-1 and fibronectin)

impaired neutrophil chemotaxis ( J:113020 )

• deficient neutrophils show increased spreading on ICAM-1 compared to wild-type cells

• in culture, neutrophil migration is severely impaired on fibronectin

• when mutant neutrophils are transferred to Listeria monocytogenes-infected mice, neutrophils are found in lower numbers in recipient livers, suggesting compromised mobilization in mutant cells

hematopoietic system

impaired neutrophil chemotaxis ( J:113020 )

• deficient neutrophils show increased spreading on ICAM-1 compared to wild-type cells

• in culture, neutrophil migration is severely impaired on fibronectin

• when mutant neutrophils are transferred to Listeria monocytogenes-infected mice, neutrophils are found in lower numbers in recipient livers, suggesting compromised mobilization in mutant cells