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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcgr1tm1Jgjw
targeted mutation 1, Jan G J van de Winkel
MGI:3664782
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcgr1tm1Jgjw/Fcgr1tm1Jgjw involves: 129 * C57BL/6 MGI:3701432


Genotype
MGI:3701432
hm1
Allelic
Composition		 Fcgr1tm1Jgjw/Fcgr1tm1Jgjw
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr1tm1Jgjw mutation (0 available); any Fcgr1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal dendritic cell differentiation ( J:112436 )
• OVA-ICs do not induce maturation of BM-DCs from mutants

immune system
abnormal dendritic cell differentiation ( J:112436 )
• OVA-ICs do not induce maturation of BM-DCs from mutants
abnormal dendritic cell antigen presentation ( J:112436 )
• mutant bone marrow-derived dendritic cells (BM-DC) treated with ovalbumin-immune complexes (OVA-IC) do not present the MHC class I-restricted epitope after OVA-IC internalization

cellular
abnormal dendritic cell differentiation ( J:112436 )
• OVA-ICs do not induce maturation of BM-DCs from mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory