Phenotypes associated with this allele

• Allele Symbol: Bdnf^tm1Flee
• Allele Name: targeted mutation 1, Francis S Lee
• Allele ID: MGI:3664862
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bdnf^tm1Flee/Bdnf^tm1Flee	B6.129-Bdnf^tm1Flee	MGI:3664863
ht2	Bdnf^tm1Flee/Bdnf^+	B6.129-Bdnf^tm1Flee	MGI:3664864

Genotype
MGI:3664863

hm1

• Allelic Composition: Bdnf^tm1Flee/Bdnf^tm1Flee
• Genetic Background: B6.129-Bdnf^tm1Flee

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:113019 )

• impaired context dependent learning but no difference in cue-dependent learning

decreased exploration in new environment ( J:113019 )

• decreased exploratory behavior as measured by percentage of time spent in the center and number of entries into the center of and open field over a 2 hour period; however no significant change in total locomotor activity is detected

increased aggression towards male mice ( J:113019 )

• intermale aggression similar to Bdnf^tm1Par heterozygotes

increased anxiety-related response ( J:113019 )

• decrease in time spent in the open arms and numbers of entries into the open arms in an elevated plus maze

• treatment with a serotonin reuptake inhibitor, fluoxetine, failed to reduce latency to drink in a test of novelty induced hypophagia and had a reduced effect on increasing the time spent in the center of an open field compared to wild-type mice

nervous system

abnormal dentate gyrus morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma

decreased hippocampus volume ( J:113019 )

• 14.4 +/- 0.7% reduction in hippocampal volume

abnormal dendrite morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma in dentate gyrus neurons

abnormal neuron physiology ( J:113019 )

• hippocampal-cortical neurons display a 29 +/- 3% decrease in regulated secretion, but no decrease in constitutive secretion, of BDNF

growth/size/body

increased body weight ( J:113019 )

• first detected at 2 months of age

Genotype
MGI:3664864

ht2

• Allelic Composition: Bdnf^tm1Flee/Bdnf⁺
• Genetic Background: B6.129-Bdnf^tm1Flee

behavior/neurological

abnormal contextual conditioning behavior ( J:113019 )

• impaired context dependent learning but no difference in cue-dependent learning

nervous system

abnormal dentate gyrus morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma

decreased hippocampus volume ( J:113019 )

• 13.7 +/- 0.7% reduction in hippocampal volume

abnormal dendrite morphology ( J:113019 )

• reduction in dendritic arbor complexity at or above 90 uM from the soma in dentate gyrus neurons

abnormal neuron physiology ( J:113019 )

• hippocampal-cortical neurons display a 18 +/- 2% decrease in regulated secretion, but no decrease in constitutive secretion, of BDNF