Phenotypes associated with this allele

• Allele Symbol: Adora2b^tm1Kra
• Allele Name: targeted mutation 1, Katya Ravid
• Allele ID: MGI:3665133
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adora2b^tm1Kra/Adora2b^tm1Kra	involves: 129 * C57BL/6J	MGI:3687263

Genotype
MGI:3687263

hm1

• Allelic Composition: Adora2b^tm1Kra/Adora2b^tm1Kra
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:111715 )

abnormal leukocyte adhesion ( J:111715 )

• more leukocytes adhere to the endothelium of mesenteric venules than in wild-type

enhanced leukocyte tethering or rolling ( J:111715 )

• exhibit more leukocytes rolling and leukocytes roll at a slower velocity in mesenteric venules than wild-type

abnormal cytokine level ( J:111715 )

• exposure to endotoxin results in augmented proinflammatory cytokine levels

abnormal interleukin level ( J:111715 )

• basal levels of IL-6 are about 2-fold higher

increased circulating interleukin-6 level ( J:111715 )

• exposure to endotoxin (LPS) results in a much greater increase in serum IL-6 than in wild-type

abnormal tumor necrosis factor level ( J:111715 )

• basal levels of TNF-alpha are about 2-fold higher

• exposure to endotoxin (LPS) results in 5-fold higher levels of serum TNF-alpha than in wild-type

decreased interleukin-10 secretion ( J:111715 )

• exposure to endotoxin (LPS) results in reduced induction of IL-10

abnormal inflammatory response ( J:111715 )

• develop low-grade inflammation

cardiovascular system

cardiovascular system phenotype ( J:111715 )

N • exhibit normal blood pressure under basal conditions and after adenosine-induced vasodilation

homeostasis/metabolism

abnormal cytokine level ( J:111715 )

• exposure to endotoxin results in augmented proinflammatory cytokine levels

abnormal interleukin level ( J:111715 )

• basal levels of IL-6 are about 2-fold higher

increased circulating interleukin-6 level ( J:111715 )

• exposure to endotoxin (LPS) results in a much greater increase in serum IL-6 than in wild-type

abnormal tumor necrosis factor level ( J:111715 )

• basal levels of TNF-alpha are about 2-fold higher

• exposure to endotoxin (LPS) results in 5-fold higher levels of serum TNF-alpha than in wild-type

cellular

abnormal leukocyte migration ( J:111715 )

abnormal leukocyte adhesion ( J:111715 )

• more leukocytes adhere to the endothelium of mesenteric venules than in wild-type

enhanced leukocyte tethering or rolling ( J:111715 )

• exhibit more leukocytes rolling and leukocytes roll at a slower velocity in mesenteric venules than wild-type

hematopoietic system

abnormal leukocyte migration ( J:111715 )

abnormal leukocyte adhesion ( J:111715 )

• more leukocytes adhere to the endothelium of mesenteric venules than in wild-type

enhanced leukocyte tethering or rolling ( J:111715 )

• exhibit more leukocytes rolling and leukocytes roll at a slower velocity in mesenteric venules than wild-type