Phenotypes associated with this allele

• Allele Symbol: Fbxw8^tm1Kei
• Allele Name: targeted mutation 1, Kenichi I Nakayama
• Allele ID: MGI:3665136
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxw8^tm1Kei/Fbxw8^tm1Kei	involves: C57BL/6	MGI:3687024
hm2	Fbxw8^tm1Kei/Fbxw8^tm1Kei	Not Specified	MGI:5319208
cx3	Fbxo4^tm1Kei/Fbxo4^tm1Kei Fbxw8^tm1Kei/Fbxw8^tm1Kei	involves: 129P2/OlaHsd * C57BL/6	MGI:5319207

Genotype
MGI:3687024

hm1

• Allelic Composition: Fbxw8^tm1Kei/Fbxw8^tm1Kei
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:111403 )

• about 50% are lost by E15.5 and 2/3 are lost by birth; however those born alive survive to adulthood and are fertile

embryonic lethality during organogenesis, incomplete penetrance ( J:111403 )

• begin to die between E11.5 and E12.5

embryo

embryonic growth retardation ( J:111403 )

• visible at E12.5

decreased embryo size ( J:111403 )

abnormal placenta morphology ( J:111403 )

• the border between the spongiotrophoblast and labyrinth layers is unclear

• placental defects are independent of maternal genotype

abnormal spongiotrophoblast layer morphology ( J:111403 )

• the spongiotrophoblast layer is thinner and irregularly protrudes into the labyrinth layer

abnormal placenta labyrinth morphology ( J:111403 )

• the spongiotrophoblast layer irregularly protrudes into the labyrinth layer

abnormal placental labyrinth vasculature morphology ( J:111403 )

• dilation of vessels in the labyrinth layer

• maternal vessel area is reduced while fetal vessel area is not significantly different from wild-type

growth/size/body

embryonic growth retardation ( J:111403 )

• visible at E12.5

decreased embryo size ( J:111403 )

respiratory system

respiratory system phenotype ( J:111403 )

N • mice that survive to E19.5 are able to properly inflate their lungs

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:111403 )

• dilation of vessels in the labyrinth layer

• maternal vessel area is reduced while fetal vessel area is not significantly different from wild-type

Genotype
MGI:5319208

hm2

• Allelic Composition: Fbxw8^tm1Kei/Fbxw8^tm1Kei
• Genetic Background: Not Specified

cellular

cellular phenotype ( J:183656 )

N • mouse embryonic fibroblasts exhibit normal cyclin D1 degradation and cell cycle progression

Genotype
MGI:5319207

cx3

• Allelic Composition: Fbxo4^tm1Kei/Fbxo4^tm1Kei; Fbxw8^tm1Kei/Fbxw8^tm1Kei
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

cellular

cellular phenotype ( J:183656 )

N • mouse embryonic fibroblasts exhibit normal cyclin D1 degradation and cell cycle progression