Phenotypes associated with this allele

• Allele Symbol: Crk^tm1.1Cur
• Allele Name: targeted mutation 1.1, Tom Curran
• Allele ID: MGI:3665145
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crk^tm1.1Cur/Crk^tm1.1Cur	involves: 129S/SvEv * C57BL/6	MGI:3665453

Genotype
MGI:3665453

hm1

• Allelic Composition: Crk^tm1.1Cur/Crk^tm1.1Cur
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:111399 )

• the few that are born die perinatally

lethality throughout fetal growth and development, incomplete penetrance ( J:111399 )

• majority die from E13.5 to E15.5, although the time of death is variable as a few embryos die later than this

homeostasis/metabolism

hydrops fetalis ( J:111399 )

• exhibit small focal edema in the midline of the craniofacial region at E12.5, mainly located on the tip of the snout and nasion

• at E13.5, the focal edema on the snout and nasion becomes enlarged and sometimes filled with blood and at E15.5, hemorrhagic edema is seen

• extensive edema is also seen on the head and back of some E13.5 and E15.5 embryos

• edema occurs at the anterior end of the nasopharynx, where nasal septum and the primary palate fuse

cardiovascular system

abnormal common carotid artery morphology ( J:111399 )

• some E15.5 embryos show marked dilation of the left common carotid artery

abnormal vascular smooth muscle morphology ( J:111399 )

• smooth muscle is sometimes discontinuous, especially near the nasal cavity

abnormal heart ventricle morphology ( J:111399 )

dilated heart left ventricle ( J:111399 )

thin ventricular wall ( J:111399 )

• thinner and contains fewer loosely packed cells

dilated heart right ventricle ( J:111399 )

hemorrhage ( J:111399 )

• observe hemorrhagic edema and hemorrhage into the lateral ventricle at E15.5

increased vasodilation ( J:111399 )

• blood vessels are dilated and rupture resulting in the hemorrhagic edema

craniofacial

palatal shelves fail to meet at midline ( J:111399 )

cleft secondary palate ( J:111399 )

• observe occasionally due to edema

abnormal nose morphology ( J:111399 )

• nasal separation is hampered due to edema in the middle of the nasal septum, although the fusion of the nasal septum with the palatal shelves and primary palate is retained

abnormal nasal mucosa morphology ( J:111399 )

• mucosal epithelium separates from the submucosa, resulting in a space filled by extracellular fluid (edema)

muscle

abnormal vascular smooth muscle morphology ( J:111399 )

• smooth muscle is sometimes discontinuous, especially near the nasal cavity

increased vasodilation ( J:111399 )

• blood vessels are dilated and rupture resulting in the hemorrhagic edema

respiratory system

abnormal nose morphology ( J:111399 )

• nasal separation is hampered due to edema in the middle of the nasal septum, although the fusion of the nasal septum with the palatal shelves and primary palate is retained

abnormal nasal mucosa morphology ( J:111399 )

• mucosal epithelium separates from the submucosa, resulting in a space filled by extracellular fluid (edema)

digestive/alimentary system

palatal shelves fail to meet at midline ( J:111399 )

cleft secondary palate ( J:111399 )

• observe occasionally due to edema

growth/size/body

palatal shelves fail to meet at midline ( J:111399 )

cleft secondary palate ( J:111399 )

• observe occasionally due to edema

abnormal nose morphology ( J:111399 )

• nasal separation is hampered due to edema in the middle of the nasal septum, although the fusion of the nasal septum with the palatal shelves and primary palate is retained

abnormal nasal mucosa morphology ( J:111399 )

• mucosal epithelium separates from the submucosa, resulting in a space filled by extracellular fluid (edema)