Phenotypes associated with this allele

• Allele Symbol: cosa
• Allele Name: cochleo-saccular defects
• Allele ID: MGI:3665149
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	cosa/cosa	SJL/J-cosa	MGI:3687025

Genotype
MGI:3687025

hm1

• Allelic Composition: cosa/cosa
• Genetic Background: SJL/J-cosa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal reflex ( J:113137 )

• lack air-righting reflex

absent startle reflex ( J:113137 )

absent vestibuloocular reflex ( J:113137 )

• lack head nystagmus reflex

impaired swimming ( J:113137 )

• unable to swim

head shaking ( J:113137 )

hyperactivity ( J:113137 )

circling ( J:113137 )

hearing/vestibular/ear

absent vestibuloocular reflex ( J:113137 )

• lack head nystagmus reflex

collapsed Reissner membrane ( J:113137 )

dilated cochlea ( J:113137 )

• at E13 the lumen of the cochlear duct is expanded especially at the basal turn and this expansion increases with age

abnormal organ of Corti morphology ( J:113137 )

• damaged but all cellular and non-cellular components are recognizable

abnormal stria vascularis morphology ( J:113137 )

• poorly developed

abnormal spiral limbus morphology ( J:113137 )

• poorly differentiated spiral limbus

abnormal inner ear canal morphology ( J:113137 )

• insufficient space for the formation of the perilymphatic canals