Phenotypes associated with this allele

• Allele Symbol: Rac1^tm1Brak
• Allele Name: targeted mutation 1, Cord Brakebusch
• Allele ID: MGI:3665172
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rac1^tm1Brak/Rac1^tm1Brak Tg(KRT5-cre)5132Jlj/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J	MGI:3665264

Genotype
MGI:3665264

cn1

• Allelic Composition: Rac1^tm1Brak/Rac1^tm1Brak; Tg(KRT5-cre)5132Jlj/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:112307 )

N • mice are fertile

endocrine/exocrine glands

enlarged sebaceous gland ( J:112307 )

• enlarged with age

pigmentation

abnormal skin pigmentation ( J:112307 )

• accumulation of melanin in the dermis and subcutis of adults

integument

enlarged sebaceous gland ( J:112307 )

• enlarged with age

abnormal coat/ hair morphology ( J:112307 )

alopecia ( J:112307 )

• progressive hair loss beginning 1 week after birth with no regrowth of hair detected through 24 months of age; however, a few evenly spaced, frail hairs remain

abnormal hair shaft morphology ( J:112307 )

• at P14 hair shafts are often misshapen with abnormal pigmentation patterns or absent

abnormal hair follicle morphology ( J:112307 )

• most nonpermanent regions of the hair follicle are lost and no regrowth of anagen hair follicles is seen in adults

• by P14 loss of differentiation specific markers and infiltration of phagocytic cells into the lower part of the hair follicle are seen

• at P9 many hair follicles with constrictions, kinks, or diffuse thickening of the hair bulb region are seen; however at P3 hair follicles appear similar to wild-type

• by P14 almost all hair follicles are abnormal with a wider lower portion and frequently no clear hair bulb

• at P14 the outer root sheath is disrupted and abnormal, large cells are seen within the hair follicle

abnormal skin pigmentation ( J:112307 )

• accumulation of melanin in the dermis and subcutis of adults

abnormal skin condition ( J:112307 )

• localized areas of mild fibrosis in adults; however, the epidermis is largely unaffected with normal appearing adherens junctions and basement membranes, and no blister formation

abnormal skin physiology ( J:112307 )

• more severe epidermal hyperthickening is seen in response to exposure to 4-hydroxy-tamoxifen in acetone; however this response is transient disappearing about 2 weeks after cessation of treatment

abnormal keratinocyte physiology ( J:112307 )

• primary keratinocytes show a severe spreading defect