Analysis Tools
mortality/aging
| N |
• viable with no signs of premature aging through 23 months of age
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reproductive system
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• endometrial hyperplasia seen in 7 of 10 virgin females between 13 and 23 months of age
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• squamous epithelial hyperplasia of the cervix is seen in 7 of 10 virgin females between 13 and 23 months of age
• however, mice are fertile
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neoplasm
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• some mammary glands display ductal carcinoma in situ, infiltrating ductal carcinoma, adenosis, and/or squamous metaplasia
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• mammary gland ductal carcinoma in situ (2 of 10 virgin females) and ductal carcinoma (2 of 10 virgin females)
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cellular
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• 45.5% of MEFs have more than 1 centrosome per nucleus compared to 13.7% of wild-type cells
• 5.5% of MEFS have more than 2 centrosomes per nucleus compared to 0.29% of wild-type cells
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• the number of cells in G1 are reduced in later passages of MEFs (more than 10 passages) and pass through G1 phase significantly faster
• however, in early passages no differences are detected and no difference in response to gamma irradiation are seen
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endocrine/exocrine glands
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• microcalcification in 5 of 10 virgin females between 13 and 23 months of age
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• some epithelial cells are detached from the ducts
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• ducts are often dilated and filled with pasty material including amorphous debris, lipids, crytstal materials, and milk
• ductal diameters near the lymph nodes are increased 2 to 10 times compared to wild-type mice
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• seen in 9 of 10 virgin females between 13 and 23 months of age with variable severity
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• some mammary glands display ductal carcinoma in situ, infiltrating ductal carcinoma, adenosis, and/or squamous metaplasia
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• mammary gland ductal carcinoma in situ (2 of 10 virgin females) and ductal carcinoma (2 of 10 virgin females)
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• lobular hyperplasia is seen in 4 of 10 virgin females between 13 and 23 months of age
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integument
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• microcalcification in 5 of 10 virgin females between 13 and 23 months of age
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• some epithelial cells are detached from the ducts
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• ducts are often dilated and filled with pasty material including amorphous debris, lipids, crytstal materials, and milk
• ductal diameters near the lymph nodes are increased 2 to 10 times compared to wild-type mice
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• seen in 9 of 10 virgin females between 13 and 23 months of age with variable severity
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• some mammary glands display ductal carcinoma in situ, infiltrating ductal carcinoma, adenosis, and/or squamous metaplasia
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• mammary gland ductal carcinoma in situ (2 of 10 virgin females) and ductal carcinoma (2 of 10 virgin females)
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• lobular hyperplasia is seen in 4 of 10 virgin females between 13 and 23 months of age
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