Analysis Tools|
Allele Symbol Allele Name Allele ID |
Aldh1a2tm1Soc targeted mutation 1, Shanthini Sockanathan MGI:3665178 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viable and fertile with no gross abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E13.5 both ventral and dorsal projecting lateral motor column neurons appear stunted or atrophied and in some cases are retracted
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• at E13.5 at the forelimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 30% and 25%, respectively; however no difference in the number of lateral motor column lateral motor neurons is detected at E12.5
• at E13.5 at the hindlimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 17% and 20%, respectively
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5 at the forelimb level, stunting of the fine branches of dorsally projecting neurons of the radial and ulnar nerves is seen; however ventral projections appear unaffected
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• about a 10% and 20% reduction in total motor neuron numbers and lateral motor column lateral motor neurons, respectively, are seen at E12.5 at the forelimb level, but no increase in cell death is detected
• at the hindlimb level at E12.5 a 14% decrease in lateral motor column lateral motor neurons is seen
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• 50% reduction in retinoic acid levels in tissue homogenates from the forelimb region
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| N |
• digit morphology and flexure of the distal limbs are similar to controls in adults
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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