Phenotypes associated with this allele

• Allele Symbol: Aldh1a2^tm2Soc
• Allele Name: targeted mutation 2, Shanthini Sockanathan
• Allele ID: MGI:3665181
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Aldh1a2^tm1Soc/Aldh1a2^tm2Soc	Not Specified	MGI:3665267
cn2	Aldh1a2^tm1Soc/Aldh1a2^tm2Soc Isl1^tm1(cre)Tmj/Isl1^+	involves: 129X1/SvJ	MGI:3665269
cn3	Aldh1a2^tm1Soc/Aldh1a2^tm2Soc Tg(Dll1-cre)1Gos/0	Not Specified	MGI:3665268

Genotype
MGI:3665267

ht1

• Allelic Composition: Aldh1a2^tm1Soc/Aldh1a2^tm2Soc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:112635 )

• viable and fertile with no gross abnormalities

Genotype
MGI:3665269

cn2

• Allelic Composition: Aldh1a2^tm1Soc/Aldh1a2^tm2Soc; Isl1^tm1(cre)Tmj/Isl1⁺
• Genetic Background: involves: 129X1/SvJ

nervous system

abnormal motor neuron innervation pattern ( J:112635 )

• at E13.5 both ventral and dorsal projecting lateral motor column neurons appear stunted or atrophied and in some cases are retracted

decreased motor neuron number ( J:112635 )

• at E13.5 at the forelimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 30% and 25%, respectively; however no difference in the number of lateral motor column lateral motor neurons is detected at E12.5

• at E13.5 at the hindlimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 17% and 20%, respectively

Genotype
MGI:3665268

cn3

• Allelic Composition: Aldh1a2^tm1Soc/Aldh1a2^tm2Soc; Tg(Dll1-cre)1Gos/0
• Genetic Background: Not Specified

nervous system

abnormal motor neuron innervation pattern ( J:112635 )

• at E12.5 at the forelimb level, stunting of the fine branches of dorsally projecting neurons of the radial and ulnar nerves is seen; however ventral projections appear unaffected

decreased motor neuron number ( J:112635 )

• about a 10% and 20% reduction in total motor neuron numbers and lateral motor column lateral motor neurons, respectively, are seen at E12.5 at the forelimb level, but no increase in cell death is detected

• at the hindlimb level at E12.5 a 14% decrease in lateral motor column lateral motor neurons is seen

homeostasis/metabolism

abnormal vitamin A level ( J:112635 )

• 50% reduction in retinoic acid levels in tissue homogenates from the forelimb region

limbs/digits/tail

limbs/digits/tail phenotype ( J:112635 )

N • digit morphology and flexure of the distal limbs are similar to controls in adults