Analysis Tools|
Allele Symbol Allele Name Allele ID |
Frem1tm1Ksek targeted mutation 1, Kiyotoshi Sekiguchi MGI:3665235 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice exhibit renal dysmorphogenesis (10 of 13 mice unilateral renal agenesis and 2 of 13 unlilateral or bilateral renal dysgenesis at E15.5)
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• unilaterally in 10 of 13 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Phenotypes and electron microscopy of Frem1tm1Ksek/Frem1tm1Ksek mice
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• exhibit subepidermal blistering occurring between the lamina densa of the basement membrane and the underlying dermis at E14.5
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• mutants exhibit complete fusion of the posterior frontal suture at postnatal day 28 compared to day 45 in controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Fraser syndrome | DOID:0090001 |
OMIM:PS219000 |
J:111788 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants exhibit variable suture abnormalities similar to Frem1bat heterozygotes
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• mutants exhibit variable suture abnormalities similar to Frem1bat heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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