All Phenotypes Trdc<tm1Mal> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Trdc^tm1Mal
targeted mutation 1, Bernard Malissen
MGI:3665255

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trdc^tm1Mal/Trdc^tm1Mal	involves: C57BL/6	MGI:3690996
cn2	Rag1^tm1.1Sadu/Rag1^tm1.1Sadu Trdc^tm1Mal/Trdc^tm1Mal Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:5438822
cx3	Lat^tm4.1Mal/Lat^tm4.1Mal Trdc^tm1Mal/Trdc^tm1Mal	involves: 129P2/OlaHsd * C57BL/6	MGI:3690995
cx4	Cd3e^tm1.1Lov/Cd3e^tm1.1Lov Trdc^tm1Mal/Trdc^tm1Mal	involves: C57BL/6	MGI:3690997
cx5	Jak3^X887Y/Jak3^X887Y Trdc^tm1Mal/Trdc^tm1Mal	involves: C57BL/6	MGI:3690998

Allelic Composition	Trdc^tm1Mal/Trdc^tm1Mal
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trdc^tm1Mal mutation (1 available); any Trdc mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:112658 )

• homozygous mice are viable, healthy, and have normal T cell development

Allelic Composition	Rag1^tm1.1Sadu/Rag1^tm1.1Sadu Trdc^tm1Mal/Trdc^tm1Mal Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (968 available)
Rag1^tm1.1Sadu mutation (0 available); any Rag1 mutation (121 available)
Trdc^tm1Mal mutation (1 available); any Trdc mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

small thymus ( J:187400 )

• in un-induced mice

• however, tamoxifen induction rescues thymus size

decreased gamma-delta T cell number ( J:187400 )

• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice

absent gamma-delta T cells ( J:187400 )

• absent IL17+ cells despite tamoxifen treatment of adult mice

increased gamma-delta T cell number ( J:187400 )

• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

hematopoietic system

small thymus ( J:187400 )

• in un-induced mice

• however, tamoxifen induction rescues thymus size

decreased gamma-delta T cell number ( J:187400 )

• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice

absent gamma-delta T cells ( J:187400 )

• absent IL17+ cells despite tamoxifen treatment of adult mice

increased gamma-delta T cell number ( J:187400 )

• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

endocrine/exocrine glands

small thymus ( J:187400 )

• in un-induced mice

• however, tamoxifen induction rescues thymus size

Allelic Composition	Lat^tm4.1Mal/Lat^tm4.1Mal Trdc^tm1Mal/Trdc^tm1Mal
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat^tm4.1Mal mutation (0 available); any Lat mutation (10 available)
Trdc^tm1Mal mutation (1 available); any Trdc mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal double-negative T cell morphology ( J:112658 )

• surface expression of Tcr gamma/delta heterodimers is normal, but stage 3 double negative (DN3) T cells are unable to mature beyond the EGFP^int Tcr gamma/delta^lo stage

• mature gamma/delta T cells are absent

• pool of EGFP^int Tcr gamma/delta^lo DN3 cells comprises ~0.5% of total DN3 cells

immune system

abnormal double-negative T cell morphology ( J:112658 )

• surface expression of Tcr gamma/delta heterodimers is normal, but stage 3 double negative (DN3) T cells are unable to mature beyond the EGFP^int Tcr gamma/delta^lo stage

• mature gamma/delta T cells are absent

• pool of EGFP^int Tcr gamma/delta^lo DN3 cells comprises ~0.5% of total DN3 cells

Allelic Composition	Cd3e^tm1.1Lov/Cd3e^tm1.1Lov Trdc^tm1Mal/Trdc^tm1Mal
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3e^tm1.1Lov mutation (0 available); any Cd3e mutation (47 available)
Trdc^tm1Mal mutation (1 available); any Trdc mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal double-negative T cell morphology ( J:112658 )

• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells

• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells

immune system

abnormal double-negative T cell morphology ( J:112658 )

• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells

• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells

Allelic Composition	Jak3^X887Y/Jak3^X887Y Trdc^tm1Mal/Trdc^tm1Mal
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3^X887Y mutation (0 available); any Jak3 mutation (84 available)
Trdc^tm1Mal mutation (1 available); any Trdc mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:112658 )

N	• Tcrd locus transcription is unaffected in Jak3-deficient mice

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