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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trdctm1Mal
targeted mutation 1, Bernard Malissen
MGI:3665255
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trdctm1Mal/Trdctm1Mal involves: C57BL/6 MGI:3690996
cn2
 		Rag1tm1.1Sadu/Rag1tm1.1Sadu
Trdctm1Mal/Trdctm1Mal
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:5438822
cx3
 		Lattm4.1Mal/Lattm4.1Mal
Trdctm1Mal/Trdctm1Mal 		involves: 129P2/OlaHsd * C57BL/6 MGI:3690995
cx4
 		Cd3etm1.1Lov/Cd3etm1.1Lov
Trdctm1Mal/Trdctm1Mal 		involves: C57BL/6 MGI:3690997
cx5
 		Jak3X887Y/Jak3X887Y
Trdctm1Mal/Trdctm1Mal 		involves: C57BL/6 MGI:3690998


Genotype
MGI:3690996
hm1
Allelic
Composition		 Trdctm1Mal/Trdctm1Mal
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:112658 )
• homozygous mice are viable, healthy, and have normal T cell development




Genotype
MGI:5438822
cn2
Allelic
Composition		 Rag1tm1.1Sadu/Rag1tm1.1Sadu
Trdctm1Mal/Trdctm1Mal
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Rag1tm1.1Sadu mutation (0 available); any Rag1 mutation (123 available)
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small thymus ( J:187400 )
• in un-induced mice
• however, tamoxifen induction rescues thymus size
decreased gamma-delta T cell number ( J:187400 )
• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice
absent gamma-delta T cells ( J:187400 )
• absent IL17+ cells despite tamoxifen treatment of adult mice
increased gamma-delta T cell number ( J:187400 )
• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

hematopoietic system
small thymus ( J:187400 )
• in un-induced mice
• however, tamoxifen induction rescues thymus size
decreased gamma-delta T cell number ( J:187400 )
• Vgamma4+ gamma delta T cells in the peripheral lymph nodes, spleen, lung and liver despite tamoxifen treatment of adult mice
absent gamma-delta T cells ( J:187400 )
• absent IL17+ cells despite tamoxifen treatment of adult mice
increased gamma-delta T cell number ( J:187400 )
• Vgamma1+ gamma delta T cells in the spleen, lung and liver despite tamoxifen treatment of adult mice

endocrine/exocrine glands
small thymus ( J:187400 )
• in un-induced mice
• however, tamoxifen induction rescues thymus size




Genotype
MGI:3690995
cx3
Allelic
Composition		 Lattm4.1Mal/Lattm4.1Mal
Trdctm1Mal/Trdctm1Mal
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lattm4.1Mal mutation (0 available); any Lat mutation (10 available)
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-negative T cell morphology ( J:112658 )
• surface expression of Tcr gamma/delta heterodimers is normal, but stage 3 double negative (DN3) T cells are unable to mature beyond the EGFPint Tcr gamma/deltalo stage
• mature gamma/delta T cells are absent
• pool of EGFPint Tcr gamma/deltalo DN3 cells comprises ~0.5% of total DN3 cells

immune system
abnormal double-negative T cell morphology ( J:112658 )
• surface expression of Tcr gamma/delta heterodimers is normal, but stage 3 double negative (DN3) T cells are unable to mature beyond the EGFPint Tcr gamma/deltalo stage
• mature gamma/delta T cells are absent
• pool of EGFPint Tcr gamma/deltalo DN3 cells comprises ~0.5% of total DN3 cells




Genotype
MGI:3690997
cx4
Allelic
Composition		 Cd3etm1.1Lov/Cd3etm1.1Lov
Trdctm1Mal/Trdctm1Mal
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd3etm1.1Lov mutation (0 available); any Cd3e mutation (54 available)
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal double-negative T cell morphology ( J:112658 )
• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells
• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells

immune system
abnormal double-negative T cell morphology ( J:112658 )
• T cells do not progress beyond the DN3 stage; expression of Tcr gamma/delta heterodimers is absent on DN3 cells
• pool of preselection cells expressing Tcr beta chains makes up ~16% of DN3 cells




Genotype
MGI:3690998
cx5
Allelic
Composition		 Jak3X887Y/Jak3X887Y
Trdctm1Mal/Trdctm1Mal
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jak3X887Y mutation (0 available); any Jak3 mutation (84 available)
Trdctm1Mal mutation (1 available); any Trdc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:112658 )
N
• Tcrd locus transcription is unaffected in Jak3-deficient mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory