Analysis Tools|
Allele Symbol Allele Name Allele ID |
CryaaL1N L1N MGI:3665274 |
| Summary |
3 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show much denser nuclear cataracts than heterozygtes at weaning age
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• at 3 weeks, wet weight of homozygous lenses is 2.87 mg compared to 3.55 mg in wild-type (7% less)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 3 weeks, wet weight of heterozygous lenses is 3.31 mg compared to 3.55 mg in wild-type (19% less)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• histology shows no obvious changes in lens epithelial and fiber cells at weaning age
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• analysis shows that mutant lenses contain a greater amount of water-insoluble crystallin proteins, likely correlating with the nuclear cataracts observed in mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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