Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cryaa2J 2 Jackson MGI:3665275 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes have very small lenses; average lens wet weight is 60% less than wild-type at weaning
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• homozygotes exhibit microphthalmia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• peripheral fiber cells of E16.5 lenses contain degenerated mitochondria with severe loss of matrix and cristae or with vacuoles
• severely disrupted actin filaments are seen in contact regions between anterior epithelial cells and posterior fiber cells in lenses at E16.5
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• altered epithelial cells and degenerated fiber cells are seen in lenses; epithelial cells are detached from or aggregated beneath the lense capsule and posterior fiber cells are only partially elongated
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• epithelium is severely altered; epithelial layer contains irregularly shaped cells and vesicle-like cellular structures, thus lacking polarized monolayer of cuboidal epithelial cells morphology seen in wild-type
• severely disrupted actin filaments are seen in contact regions between anterior epithelial cells and posterior fiber cells in lenses at E16.5
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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