Phenotypes associated with this allele

• Allele Symbol: Il23r^tm1Dnax
• Allele Name: targeted mutation 1, DNAX Research Institute of Cellular and Molecular Biology
• Allele ID: MGI:3665279
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il23r^tm1Dnax/Il23r^tm1Dnax	C57BL/6-Il23r^tm1Dnax	MGI:3691134

Genotype
MGI:3691134

hm1

• Allelic Composition: Il23r^tm1Dnax/Il23r^tm1Dnax
• Genetic Background: C57BL/6-Il23r^tm1Dnax

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:111568 )

N • no phenotype was described except for the response to challenge with tumor cells

N • inhibition of growth of injected B16F10 melanoma and LL2 lung carcinoma cells

N • growth of PDV6 squamous carcinoma cells is reduced compared to wild-type but increased compared to mice unable to respond to IL12

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:124591 )

• mice do not exhibit epidermal hyperplasia in response to intradermal IL-23 treatment