Phenotypes associated with this allele

• Allele Symbol: Rock1^tm1Liao
• Allele Name: targeted mutation 1, James K Liao
• Allele ID: MGI:3665285
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rock1^tm1Liao/Rock1^+	C57BL/6-Rock1^tm1Liao	MGI:3687016

Genotype
MGI:3687016

ht1

• Allelic Composition: Rock1^tm1Liao/Rock1⁺
• Genetic Background: C57BL/6-Rock1^tm1Liao

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal vascular smooth muscle morphology ( J:135152 )

• following carotid artery ligation, vascular smooth muscle proliferation and survival are decreased compared to in wild-type mice

abnormal vascular endothelial cell physiology ( J:135152 )

• thrombin-stimulated endothelial cells do not exhibit U937-LAM (U937 monocytes expressing human L selectin) adherence under laminar flow unlike wild-type cells

abnormal vascular wound healing ( J:135152 )

• flow cessation caused by ligation of the left common carotid artery produces a smaller increase in neointima formation than in wild-type mice due to decreased proliferation

• bone marrow derived cells form decreased neointima after carotid ligation compared to wild-type bone marrow-derived cells

• however, mice transplanted with wild-type bone marrow exhibit normal neointima formation following carotid artery ligation

immune system

abnormal leukocyte migration ( J:135152 )

• following carotid artery ligation, recruitment of leukocyte is decreased compared to in wild-type mice

• following thioglycollate-induced peritonitis, leukocyte chemotaxis, accumulation and adherence are impaired compared to in wild-type mice

• mice receiving bone marrow transplants exhibit decreased leukocyte recruitment following carotid artery ligation compared to mice receiving wild-type bone marrow transfers

impaired macrophage chemotaxis ( J:135152 )

• following carotid artery ligation or thioglycollate-induced peritonitis, recruitment of macrophage is decreased compared to in wild-type mice

abnormal leukocyte adhesion ( J:135152 )

• impaired following thioglycollate-induced peritonitis

impaired neutrophil recruitment ( J:135152 )

• following thioglycollate-induced peritonitis

muscle

abnormal vascular smooth muscle morphology ( J:135152 )

• following carotid artery ligation, vascular smooth muscle proliferation and survival are decreased compared to in wild-type mice

homeostasis/metabolism

abnormal vascular wound healing ( J:135152 )

• flow cessation caused by ligation of the left common carotid artery produces a smaller increase in neointima formation than in wild-type mice due to decreased proliferation

• bone marrow derived cells form decreased neointima after carotid ligation compared to wild-type bone marrow-derived cells

• however, mice transplanted with wild-type bone marrow exhibit normal neointima formation following carotid artery ligation

respiratory system

abnormal respiratory system physiology ( J:112242 )

• exposure of murine lung endothelial cells to high glucose conditions fails to increase Serpine1 protein levels as in wild-type murine lung endothelial cells

cellular

abnormal leukocyte migration ( J:135152 )

• following carotid artery ligation, recruitment of leukocyte is decreased compared to in wild-type mice

• following thioglycollate-induced peritonitis, leukocyte chemotaxis, accumulation and adherence are impaired compared to in wild-type mice

• mice receiving bone marrow transplants exhibit decreased leukocyte recruitment following carotid artery ligation compared to mice receiving wild-type bone marrow transfers

impaired macrophage chemotaxis ( J:135152 )

• following carotid artery ligation or thioglycollate-induced peritonitis, recruitment of macrophage is decreased compared to in wild-type mice

abnormal leukocyte adhesion ( J:135152 )

• impaired following thioglycollate-induced peritonitis

hematopoietic system

abnormal leukocyte migration ( J:135152 )

• following carotid artery ligation, recruitment of leukocyte is decreased compared to in wild-type mice

• following thioglycollate-induced peritonitis, leukocyte chemotaxis, accumulation and adherence are impaired compared to in wild-type mice

• mice receiving bone marrow transplants exhibit decreased leukocyte recruitment following carotid artery ligation compared to mice receiving wild-type bone marrow transfers

impaired macrophage chemotaxis ( J:135152 )

• following carotid artery ligation or thioglycollate-induced peritonitis, recruitment of macrophage is decreased compared to in wild-type mice

abnormal leukocyte adhesion ( J:135152 )

• impaired following thioglycollate-induced peritonitis

impaired neutrophil recruitment ( J:135152 )

• following thioglycollate-induced peritonitis