Phenotypes associated with this allele

• Allele Symbol: Cytip^tm1Wtw
• Allele Name: targeted mutation 1, Wendy T Watford
• Allele ID: MGI:3665293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cytip^tm1Wtw/Cytip^tm1Wtw	involves: 129S6/SvEvTac * C57BL/6	MGI:3690324

Genotype
MGI:3690324

hm1

• Allelic Composition: Cytip^tm1Wtw/Cytip^tm1Wtw
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:112168 )

N • mutants show normal lymphocyte development and normal innate immunity

abnormal response to transplant ( J:112168 )

• 8 weeks following transplant of wild-type and mutant ES cells (1:1) into Rag2-deficient mice, mutant ES cells show a mild competitive disadvantage in reconstitution of hematopoietic compartments, particularly in generation of CD8+ T cells; generation of splenic B cells and B220-CD11c+ dendritic cells is also modestly impaired