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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		P2rx4tm1Rass
targeted mutation 1, Francois Rassendren PhD
MGI:3665297
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		P2rx4tm1Rass/P2rx4tm1Rass B6.Cg-P2rx4tm1Rass MGI:3690323


Genotype
MGI:3690323
hm1
Allelic
Composition		 P2rx4tm1Rass/P2rx4tm1Rass
Genetic
Background		 B6.Cg-P2rx4tm1Rass
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
P2rx4tm1Rass mutation (0 available); any P2rx4 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:112177 )
• after Schaffer collateral stimulation in CA1 hippocampal slices which caused a sustained increased in amplitude of field EPSP, magnitude of LTP is lower (136% of baseline) than in wild-type (169% of baseline)
• ivermectin treatment increases LTP in hippocampal slices from wild-type mice, but has no effect in mutant slices




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory