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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Seletm1Dmil
targeted mutation 1, David Milstone
MGI:3665314
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Seletm1Dmil/Seletm1Dmil involves: 129S4/SvJae * C57BL/6J MGI:3690074


Genotype
MGI:3690074
hm1
Allelic
Composition		 Seletm1Dmil/Seletm1Dmil
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Dmil mutation (3 available); any Sele mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte adhesion ( J:113169 )
• TNFa treatment to stimulate an inflammatory response resulted in a significantly lower amount of adhesion in mutants vs wild-type
• numbers of adherent cells in wild-type prior to treatment is 74 adherent cells/sq. mm and in mutants 83 cells/sq. mm.; after TNF treatment, in wild-type there are 1745 adherent cells/sq. mm while in mutants there are 798 cells/sq. mm
• in mutants, fewer dermal microvessels support high adhesion densities compared to wild-type mice; a similar trend is observed in mesenteric microvessels

cellular
abnormal leukocyte adhesion ( J:113169 )
• TNFa treatment to stimulate an inflammatory response resulted in a significantly lower amount of adhesion in mutants vs wild-type
• numbers of adherent cells in wild-type prior to treatment is 74 adherent cells/sq. mm and in mutants 83 cells/sq. mm.; after TNF treatment, in wild-type there are 1745 adherent cells/sq. mm while in mutants there are 798 cells/sq. mm
• in mutants, fewer dermal microvessels support high adhesion densities compared to wild-type mice; a similar trend is observed in mesenteric microvessels

hematopoietic system
abnormal leukocyte adhesion ( J:113169 )
• TNFa treatment to stimulate an inflammatory response resulted in a significantly lower amount of adhesion in mutants vs wild-type
• numbers of adherent cells in wild-type prior to treatment is 74 adherent cells/sq. mm and in mutants 83 cells/sq. mm.; after TNF treatment, in wild-type there are 1745 adherent cells/sq. mm while in mutants there are 798 cells/sq. mm
• in mutants, fewer dermal microvessels support high adhesion densities compared to wild-type mice; a similar trend is observed in mesenteric microvessels




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11/12/2024
MGI 6.24 		The Jackson Laboratory