Analysis Tools
reproductive system
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• in addition to reduced testes size, remainder of reproductive tract is hypoplastic
• histological analysis of proximal portion of male reproductive tract shows structures with coiled morphology and folded epithelium structure of oviduct
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• at E13.5, male testicular development, including Sertoli cell location and numbers appears normal, but from E15.5 to P7, development is abnormal
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• testes completely lack normal tubular architecture of controls and consist primarily of sheets of eosinophilic cells
• at E15.5, only a few tubule-like structures are observed
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• testes contain sheets of eosinophilic cells identified histologically as Leydig cells; these cells are observed in dense clusters interspersed with regions of fibroblast-like cells
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small testis
(
J:111787
)
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• in 7 week old males, testes size is ~10% of control wild-type littermates
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• males have a uterus in addition to vas deferens, epididymis, and seminal vesicles
• histological analysis of proximal portion of male reproductive tract shows structures with coiled morphology and folded epithelium structure of oviduct
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• based on aberrant structure of male testes, males are predicted to be sterile
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endocrine/exocrine glands
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• at E13.5, male testicular development, including Sertoli cell location and numbers appears normal, but from E15.5 to P7, development is abnormal
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• testes completely lack normal tubular architecture of controls and consist primarily of sheets of eosinophilic cells
• at E15.5, only a few tubule-like structures are observed
|
|
|
• testes contain sheets of eosinophilic cells identified histologically as Leydig cells; these cells are observed in dense clusters interspersed with regions of fibroblast-like cells
|
small testis
(
J:111787
)
|
|
• in 7 week old males, testes size is ~10% of control wild-type littermates
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