About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grm2tm1Ddsc
targeted mutation 1, Darryle D Schoepp
MGI:3665323
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grm2tm1Ddsc/Grm2tm1Ddsc involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3690071


Genotype
MGI:3690071
hm1
Allelic
Composition		 Grm2tm1Ddsc/Grm2tm1Ddsc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm2tm1Ddsc mutation (0 available); any Grm2 mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:113260 )
• injection of LY354740, an mGlu2/3r agonist, 30 minutes prior to testing, induced anxiolytic-like effects in 5 week old male wild-type as shown by increased time spent in the open and number of open-arm entries in the elevated-plus maze (EPM) test; in contrast, male mutants showed no decrease in anxiety-related behavior with LY354740 treatment




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory