All Phenotypes Sez6l2<tm1Hta> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sez6l2^tm1Hta
targeted mutation 1, Hiroshi Takeshima
MGI:3665419

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sez6l2^tm1Hta/Sez6l2^tm1Hta	involves: 129 * C57BL	MGI:3688099
cx2	Sez6^tm1Hta/Sez6^tm1Hta Sez6l2^tm1Hta/Sez6l2^tm1Hta	involves: 129 * C57BL	MGI:3688100
cx3	Sez6^tm1Hta/Sez6^tm1Hta Sez6l^tm1Hta/Sez6l^tm1Hta Sez6l2^tm1Hta/Sez6l2^tm1Hta	involves: 129 * C57BL	MGI:3688101

Allelic Composition	Sez6l2^tm1Hta/Sez6l2^tm1Hta
Genetic Background	involves: 129 * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sez6l2^tm1Hta mutation (0 available); any Sez6l2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:111556 )

• mice do not show clear abnormalities

Allelic Composition	Sez6^tm1Hta/Sez6^tm1Hta Sez6l2^tm1Hta/Sez6l2^tm1Hta
Genetic Background	involves: 129 * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sez6l2^tm1Hta mutation (0 available); any Sez6l2 mutation (33 available)
Sez6^tm1Hta mutation (0 available); any Sez6 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:111556 )

• mice show normal motor performance compared to wild-type

Allelic Composition	Sez6^tm1Hta/Sez6^tm1Hta Sez6l^tm1Hta/Sez6l^tm1Hta Sez6l2^tm1Hta/Sez6l2^tm1Hta
Genetic Background	involves: 129 * C57BL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sez6l2^tm1Hta mutation (0 available); any Sez6l2 mutation (33 available)
Sez6l^tm1Hta mutation (0 available); any Sez6l mutation (43 available)
Sez6^tm1Hta mutation (0 available); any Sez6 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired coordination ( J:111556 )

• in a thin rod test, null mice walk slowly and essentially are crawling along bar, compared to wild-type which traverse bar quickly and proficiently; mutant mice frequently stop and curl tail around bar

• in a rotarod test, null mice fail to stay on bar, showing significant impairment in all trials with little improvement

nervous system

abnormal Purkinje cell innervation ( J:111556 )

• Purkinje cell dendritic innervation by climbing fibers is abnormal; there is evidence of multiple innervation, with dendrites showing innervation by two climbing fibers

abnormal excitatory postsynaptic currents ( J:111556 )

• a higher percentage of Purkinje cells (PCs) in cerebellar slices display 2 or more discrete EPSCs than wild-type Purkinje cells

• PCs with multiple EPSCs have EPSCs with small amplitudes and slow rise times compared to wild-type

• EPSCs are elicited in all-or-none fashion and show paired-pulse depression in mutants

biphasic excitatory postsynaptic current amplitude ( J:111556 )

decreased excitatory postsynaptic current amplitude ( J:111556 )

short excitatory postsynaptic current rise time ( J:111556 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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