Phenotypes associated with this allele

• Allele Symbol: Gabbr1^tm3Bet
• Allele Name: targeted mutation 3, Bernhard Bettler
• Allele ID: MGI:3665432
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabbr1^tm3Bet/Gabbr1^tm3Bet	BALB/c-Gabbr1^tm3Bet	MGI:3688146

Genotype
MGI:3688146

hm1

• Allelic Composition: Gabbr1^tm3Bet/Gabbr1^tm3Bet
• Genetic Background: BALB/c-Gabbr1^tm3Bet

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal conditioned taste aversion behavior ( J:111889 )

• fail to display avoidance to saccharin containing water when LiCl treatment is paired with saccharin exposure, unlike wild-type mice

abnormal object recognition memory ( J:113340 )

• fail to discriminate between novel and familiar objects

nervous system

abnormal excitatory postsynaptic currents ( J:113340 , J:276486 )

• baclofen fails to reduce EPSC amplitude in CA1 pyramidal neurons; however, baclofen does reduce inhibitory postsynaptic current amplitudes and elicits outward currents similar to the effects in wild-type mice (J:113340)

• increased frequency of spontaneous miniature ESPCs; however, the amplitude ratio of evoked EPSCs in response to paired-pulse stimulation is similar to wild-type (J:113340)

• increase in the coefficient of variation (CV) of the AMPA receptor mediated component of the EPSC is decreased while the CV of the NMDA receptor mediated component of the EPSC is similar to wild-type suggesting a decrease in the proportion of silent synapses (J:113340)

• less efficient in baclofen-induced reduction of mEPSC frequency that is more pronounced in hippocampal slices from App^tm1Somm homozygotes (J:276486)

reduced long-term potentiation ( J:113340 )

• no notable LTP in a paired protocol of CA3 to CA1 synapses