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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Neo1Gt(KST265)Byg
gene trap KST265, BayGenomics
MGI:3665445
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Neo1Gt(KST265)Byg/Neo1Gt(KST265)Byg B6.129P2-Neo1Gt(KST265)Byg MGI:3665467
hm2
 		Neo1Gt(KST265)Byg/Neo1Gt(KST265)Byg involves: 129P2/OlaHsd MGI:3665463


Genotype
MGI:3665467
hm1
Allelic
Composition		 Neo1Gt(KST265)Byg/Neo1Gt(KST265)Byg
Genetic
Background		 B6.129P2-Neo1Gt(KST265)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neo1Gt(KST265)Byg mutation (1 available); any Neo1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal trigeminal nerve morphology ( J:109043 )
• at E11.5, the ophthalmic branch of the developing trigeminal nerve is absent; however, no trochlear nerve abnormalities are detected and diaphragm innervation is similar to wild-type at E18.5




Genotype
MGI:3665463
hm2
Allelic
Composition		 Neo1Gt(KST265)Byg/Neo1Gt(KST265)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neo1Gt(KST265)Byg mutation (1 available); any Neo1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

endocrine/exocrine glands
abnormal mammary gland development ( J:109023 )
• terminal end buds of mammary gland explants are abnormal similar to NtnGt(pGT1.8TM)629Wcs homozygous explants
• terminal end buds are also disorganized
• an 8-fold increase in apoptosis is seen in detached cap cells
• growth of explants is slower compared to wild-type

integument
abnormal mammary gland development ( J:109023 )
• terminal end buds of mammary gland explants are abnormal similar to NtnGt(pGT1.8TM)629Wcs homozygous explants
• terminal end buds are also disorganized
• an 8-fold increase in apoptosis is seen in detached cap cells
• growth of explants is slower compared to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory