Phenotypes associated with this allele

• Allele Symbol: Pla2r1^tm1Itoh
• Allele Name: targeted mutation 1, Takeshi Itoh
• Allele ID: MGI:3686614
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2r1^tm1Itoh/Pla2r1^tm1Itoh	involves: 129P2/OlaHsd * C57BL/6	MGI:3686616

Genotype
MGI:3686616

hm1

• Allelic Composition: Pla2r1^tm1Itoh/Pla2r1^tm1Itoh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:313998 )

• mice exhibit increased spontaneous tumor formation with age, with two mice showing tumors, a lung adenoma and a colon adenoma, at 12 months of age

• approximately 50% of mice display macroscopic lesions at 20 months of age compared to 11% of controls

• the number of lesions per mouse at 20 months of age is higher than in controls

• both benign and malignant lesions are seen

• lesions include ovarian cystadenoma, benign serous ovarian cyst, lymphoma, metastatic lymphoma in the liver, intestinal adenocarcinoma, and histiocytic sarcoma

immune system

decreased susceptibility to endotoxin shock ( J:44868 )

• mice are otherwise viable and fertile with no overt abnormalities

• at 20 mg/kg, LPS lethality was 36% for control mice, in contrast to 0% for mutant mice after 24 h treatment

• injection of lipopolysaccharide (LPS) in control mice (30 mg/kg) induced 46% lethality by 17h after challenge, whereas mutant mice all survived; at 24 h after LPS injection, survival rate was only 8% for control mice compared with 50% for mutant mice