All Phenotypes Tg(HIST1H2BB/EGFP)1Pa MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(HIST1H2BB/EGFP)1Pa
transgene insertion 1, Virginia E Papaioannou
MGI:3686857

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Krt14^tm1(cre)Wbm/Krt14⁺ Pard3^tm1Shoh/Pard3^tm1Shoh Tg(HIST1H2BB/EGFP)1Pa/0	involves: 129 * C57BL/6J	MGI:6272614
cx2	Bub1b^tm1.1Hsl/Bub1b⁺ Tg(HIST1H2BB/EGFP)1Pa/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5543392
tg3	Tg(HIST1H2BB/EGFP)1Pa/Tg(HIST1H2BB/EGFP)1Pa	involves: 129S1/Sv * 129X1/SvJ * ICR	MGI:3687146

Allelic Composition	Krt14^tm1(cre)Wbm/Krt14⁺ Pard3^tm1Shoh/Pard3^tm1Shoh Tg(HIST1H2BB/EGFP)1Pa/0
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt14^tm1(cre)Wbm mutation (0 available); any Krt14 mutation (38 available)
Pard3^tm1Shoh mutation (0 available); any Pard3 mutation (96 available)
Tg(HIST1H2BB/EGFP)1Pa mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanocyte morphology ( J:240961 )

• in P58 tail whole mounts, melanocytes (MCs) show a more stubby dendritic morphology with dendritic shortening and a more spread cell body area relative to MCs in control mice

Allelic Composition	Bub1b^tm1.1Hsl/Bub1b⁺ Tg(HIST1H2BB/EGFP)1Pa/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bub1b^tm1.1Hsl mutation (0 available); any Bub1b mutation (59 available)
Tg(HIST1H2BB/EGFP)1Pa mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:201641 )

• micronuclei due to lagging chromosomes in mouse embryonic fibroblasts, regenerating hepatocytes and hepatocellular carcinoma

aneuploidy ( J:201641 )

• in mouse embryonic fibroblasts

abnormal mitosis ( J:201641 )

• premature sister chromatid separation in mouse embryonic fibroblasts

• shortened mitotic timing

abnormal mitotic spindle assembly checkpoint ( J:201641 )

• weakened with chromosome mis-segregation, congression failure and severe defects in kinetochore-microtubule attachment in mouse embryonic fibroblasts

Allelic Composition	Tg(HIST1H2BB/EGFP)1Pa/Tg(HIST1H2BB/EGFP)1Pa
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HIST1H2BB/EGFP)1Pa mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:109836 )

• homozygotes are viable and fertile; the reporter is developmentally neutral

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