immune system
• by bone marrow derived dendritic cells in response to phenol-purified LPS with ATP and commercial LPS
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Allele Symbol Allele Name Allele ID |
Nlrp3tm1Flv targeted mutation 1, Richard A Flavell MGI:3686871 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• by bone marrow derived dendritic cells in response to phenol-purified LPS with ATP and commercial LPS
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• dextran sodium sulfate (DSS)-treated mice housed with wild-type mice exhibit attenuated colitis compared with wild-type mice
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• dextran sodium sulfate (DSS)-treated mice housed with wild-type mice exhibit attenuated colitis compared with wild-type mice
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• do not process caspase-1 and secrete less IL1B in response to LPS and ATP treatment
• impaired secretion of IL1A, IL1B and IL18 in TLR-primed and ATP-treated cells; however secretion of TNFA, IL6, and IL12 are similar to wild-type
• absence of bacterial muramyl dipeptide-stimulated IL1B secretion
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• significant decrease in serum IL1B levels after challenge with 37.5 mg/kg of LPS
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• significant decrease in serum IL18 levels after challenge with 37.5 mg/kg of LPS
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• no difference in the degree of ear swelling between sensitized (with trinitrophenylchloride) and naive mice
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• with lower doses of LPS (18.75 and 9.38 mg/kg) mortality is delayed or reduced, respectively, compared to wild-type mice
• however with a high dose of LPS ((37.5 mg/kg) no difference in the time course of incidence of mortality is seen and the time course of macrophage cell death in response to Salmonella tymphimurium is similar to wild-type
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• significant decrease in serum IL1B levels after challenge with 37.5 mg/kg of LPS
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• significant decrease in serum IL18 levels after challenge with 37.5 mg/kg of LPS
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• do not process caspase-1 and secrete less IL1B in response to LPS and ATP treatment
• impaired secretion of IL1A, IL1B and IL18 in TLR-primed and ATP-treated cells; however secretion of TNFA, IL6, and IL12 are similar to wild-type
• absence of bacterial muramyl dipeptide-stimulated IL1B secretion
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice die between 2 and 14 days after birth probably due to multisystem organ failure secondary to inflammation and necrosis
• genotype demonstrates inflammatory disease of the conditional allele does not require presence of wild-type allele
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• mice have pronounced leukocytic infiltrates in skin, liver, spleen, joint, sinus, conjunctiva, bone marrow, and tongue that are mainly neutrophilic
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• when infected with 105 Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
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• when infected with 105 Salmonella typhimurium, mice succumb within the same timeframe as Slc11a1s homozygotes
• when infected with 105 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased similar to in Slc11a1s homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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