Phenotypes associated with this allele

• Allele Symbol: Bank1^tm1Kuro
• Allele Name: targeted mutation 1, Tomohiro Kurosaki
• Allele ID: MGI:3686872
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bank1^tm1Kuro/Bank1^tm1Kuro	Not Specified	MGI:3687152
cx2	Bank1^tm1Kuro/Bank1^tm1Kuro Cd40^tm1Kik/Cd40^tm1Kik	involves: 129P2/OlaHsd	MGI:3687154

Genotype
MGI:3687152

hm1

• Allelic Composition: Bank1^tm1Kuro/Bank1^tm1Kuro
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased mature B cell number ( J:113321 )

• slight increase in the numbers and percentages of mature splenic B cells, peritoneal B1-a B cells, and bone marrow recirculating B cells

increased B-1a cell number ( J:113321 )

abnormal spleen germinal center morphology ( J:113321 )

increased spleen germinal center number ( J:113321 )

• increase in the number of spontaneously forming germinal centers

increased spleen germinal center size ( J:113321 )

• following T cell dependent antigen stimulation an increase in the size but not in the number of germinal centers is seen compared to antigen stimulated wild-type mice

abnormal splenic cell ratio ( J:113321 )

• increase in the ratio of B to T cells

abnormal lymphocyte physiology ( J:113321 )

• hyperresponsive to T cell dependent primary responses but not to T cell dependent secondary responses

abnormal B cell physiology ( J:113321 )

• enhanced survival following CD40 stimulation

increased B cell proliferation ( J:113321 )

• following CD40 stimulation

increased IgG2a level ( J:113321 )

• increased basal IgG2a levels

• however, IgG1 response to TNP-KLH stimulation is similar to wild-type

increased IgM level ( J:113321 )

• increased IgM in mice immunized with TNP-KLH compared to immunized wild-type mice

hematopoietic system

increased mature B cell number ( J:113321 )

• slight increase in the numbers and percentages of mature splenic B cells, peritoneal B1-a B cells, and bone marrow recirculating B cells

increased B-1a cell number ( J:113321 )

abnormal spleen germinal center morphology ( J:113321 )

increased spleen germinal center number ( J:113321 )

• increase in the number of spontaneously forming germinal centers

increased spleen germinal center size ( J:113321 )

• following T cell dependent antigen stimulation an increase in the size but not in the number of germinal centers is seen compared to antigen stimulated wild-type mice

abnormal splenic cell ratio ( J:113321 )

• increase in the ratio of B to T cells

abnormal lymphocyte physiology ( J:113321 )

• hyperresponsive to T cell dependent primary responses but not to T cell dependent secondary responses

abnormal B cell physiology ( J:113321 )

• enhanced survival following CD40 stimulation

increased B cell proliferation ( J:113321 )

• following CD40 stimulation

increased IgG2a level ( J:113321 )

• increased basal IgG2a levels

• however, IgG1 response to TNP-KLH stimulation is similar to wild-type

increased IgM level ( J:113321 )

• increased IgM in mice immunized with TNP-KLH compared to immunized wild-type mice

cellular

increased B cell proliferation ( J:113321 )

• following CD40 stimulation

Genotype
MGI:3687154

cx2

• Allelic Composition: Bank1^tm1Kuro/Bank1^tm1Kuro; Cd40^tm1Kik/Cd40^tm1Kik
• Genetic Background: involves: 129P2/OlaHsd

immune system

immune system phenotype ( J:113321 )

N • increased IgM response and germinal center formation seen in Bank1 single homozygotes are absent in double homozygotes