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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf1atm2Gkl
targeted mutation 2, George Kollias
MGI:3686874
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tnfrsf1atm1Blt/Tnfrsf1atm2Gkl
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * 129S/SvEv MGI:3687172
cn2
 		Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/0 		involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA MGI:6195614
cn3
 		Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/? 		involves: 129S/SvEv * C57BL/6 * CBA MGI:3775437
cn4
 		Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(KRT14-cre)1Cgn/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:5582488
cn5
 		Tnfrsf1atm2Gkl/Tnfrsf1a+
Tg(Vil1-cre)997Gum/0 		involves: 129S/SvEv * C57BL/6J * SJL MGI:5573126


Genotype
MGI:3687172
cn1
Allelic
Composition		 Tnfrsf1atm1Blt/Tnfrsf1atm2Gkl
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cr2-cre)3Cgn mutation (2 available)
Tnfrsf1atm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:113314 )
N
• architecture of all secondary lymphoid organs is similar to wild-type




Genotype
MGI:6195614
cn2
Allelic
Composition		 Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col6a1-cre)1Gkl mutation (1 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:264147 )
N
• aortic valves appear normal at 16 weeks of age, showing no signs of disease




Genotype
MGI:3775437
cn3
Allelic
Composition		 Tnftm2Gkl/Tnf+
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(Col6a1-cre)1Gkl/?
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Col6a1-cre)1Gkl mutation (1 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
small intestinal inflammation ( J:131930 )
• the ileum contains inflammatory pathology reminiscent of Crohn's disease
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers
• 100% of mice have disease by 8 weeks of age

immune system
small intestinal inflammation ( J:131930 )
• the ileum contains inflammatory pathology reminiscent of Crohn's disease
• pathology includes blunting of intestinal villi, and infiltration of inflammation cells into the mucosal and submucosal layers
• 100% of mice have disease by 8 weeks of age
autoimmune arthritis ( J:131930 )
• 100% of mice have arthritis by 8 weeks of age
• joints are infiltrated by mononuclear cells
• mice also develop spondyloarthritis in their sacroiliac joints

skeleton
autoimmune arthritis ( J:131930 )
• 100% of mice have arthritis by 8 weeks of age
• joints are infiltrated by mononuclear cells
• mice also develop spondyloarthritis in their sacroiliac joints




Genotype
MGI:5582488
cn4
Allelic
Composition		 Ikbkbtm1Cgn/Ikbkbtm1Cgn
Tnfrsf1atm2Gkl/Tnfrsf1atm2Gkl
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation (0 available); any Ikbkb mutation (56 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
skin inflammation ( J:208995 )
• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
skin lesions ( J:208995 )
• milder at P7 than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• skin lesions progressively develop to severe skin inflammation by 4 weeks

immune system
skin inflammation ( J:208995 )
• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks




Genotype
MGI:5573126
cn5
Allelic
Composition		 Tnfrsf1atm2Gkl/Tnfrsf1a+
Tg(Vil1-cre)997Gum/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Vil1-cre)997Gum mutation (2 available)
Tnfrsf1atm2Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
abnormal intestine physiology ( J:210950 )
• increased intestinal permeability in mice challenged with TNF




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory