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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk1tm1.1Hed
targeted mutation 1.1, Stephen M Hedrick
MGI:3686888
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mapk1tm1.1Hed/Mapk1tm1.1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd 		involves: 129 MGI:5508241
cn2
 		Krastm1Bbd/Kras+
Mapk1tm1.1Hed/Mapk1tm1.1Hed 		involves: 129S1/Sv * 129X1/SvJ MGI:5508239
cn3
 		Krastm1Bbd/Kras+
Mapk1tm1.1Hed/Mapk1tm1.1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg 		involves: 129/Sv * 129S1/Sv * 129X1/SvJ MGI:5508240
cn4
 		Mapk1tm1.1Hed/Mapk1tm1.1Hed
Tg(Lck-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:3687233


Genotype
MGI:5508241
cn1
Allelic
Composition		 Mapk1tm1.1Hed/Mapk1tm1.1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1.1Hed mutation (0 available); any Mapk1 mutation (43 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Polr2atm1(cre/ERT2)Bbd mutation (3 available); any Polr2a mutation (92 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:172200 )
• mice fed a tamoxifen-containing diet show a deterioration of health and die within 3 weeks due to multiple organ failure




Genotype
MGI:5508239
cn2
Allelic
Composition		 Krastm1Bbd/Kras+
Mapk1tm1.1Hed/Mapk1tm1.1Hed
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation (2 available); any Kras mutation (84 available)
Mapk1tm1.1Hed mutation (0 available); any Mapk1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:172200 )
• 50% survival at 34.9 weeks versus 31.2 weeks in single Kras mutants following intratracheal instillation of Ad-Cre, indicating a 16% increase in survival

neoplasm
increased lung non-small cell carcinoma incidence ( J:172200 )
• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre); tumor burden in similar to that seen in single Kras heterozygotes

respiratory system
increased lung non-small cell carcinoma incidence ( J:172200 )
• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre); tumor burden in similar to that seen in single Kras heterozygotes




Genotype
MGI:5508240
cn3
Allelic
Composition		 Krastm1Bbd/Kras+
Mapk1tm1.1Hed/Mapk1tm1.1Hed
Mapk3tm1Gpg/Mapk3tm1Gpg
Genetic
Background		 involves: 129/Sv * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation (2 available); any Kras mutation (84 available)
Mapk1tm1.1Hed mutation (0 available); any Mapk1 mutation (43 available)
Mapk3tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:172200 )
• following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), mutants show 50% survival at 63 weeks versus 48 weeks in single Kras mutants, a 40% increase in survival

neoplasm
decreased classified tumor incidence ( J:172200 )
• 6 months following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), only a few tumors are observed; tumors that are found express normal levels of Mapk1




Genotype
MGI:3687233
cn4
Allelic
Composition		 Mapk1tm1.1Hed/Mapk1tm1.1Hed
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm1.1Hed mutation (0 available); any Mapk1 mutation (43 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme level ( J:113280 )
• Mapk1 protein levels are decreased ~3-fold at the DN3 stage and from 25-100-fold at the DN4 stage

immune system
abnormal T cell subpopulation ratio ( J:113280 )
• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation
decreased CD4-positive, alpha-beta T cell number ( J:113280 )
• there is a larger decrease in CD4 T cells than CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
decreased CD8-positive, alpha-beta T cell number ( J:113280 )
• there is a decrease in CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type

hematopoietic system
abnormal T cell subpopulation ratio ( J:113280 )
• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation
decreased CD4-positive, alpha-beta T cell number ( J:113280 )
• there is a larger decrease in CD4 T cells than CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type
decreased CD8-positive, alpha-beta T cell number ( J:113280 )
• there is a decrease in CD8 T cells; ratio of CD4:CD8 goes down to 2.2 from 3.2 in wild-type




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory