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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk1tm2Hed
targeted mutation 2, Stephen M Hedrick
MGI:3686889
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk1tm2Hed/Mapk1tm2Hed involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3687230
ht2
 		Mapk1tm2Hed/Mapk1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3687231


Genotype
MGI:3687230
hm1
Allelic
Composition		 Mapk1tm2Hed/Mapk1tm2Hed
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Hed mutation (0 available); any Mapk1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:113280 )
• no homozygous mice are generated from 60 heterozygous matings




Genotype
MGI:3687231
ht2
Allelic
Composition		 Mapk1tm2Hed/Mapk1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Hed mutation (0 available); any Mapk1 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:113280 )
• transmission of deficient allele decreases with each generation in backcrosses to C57BL/6 such that by F4, there is only one male heterozygote out of 37 offspring
• background sensitivity when an F3 heterozygote is backcrossed to 129/Sv, the mutant allele shows 54% transmission




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory