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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il4tm1(CD2)Mmrs
targeted mutation 1, Markus Mohrs
MGI:3686902
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs involves: 129 MGI:5313997
ht2
 		Il4tm1(CD2)Mmrs/Il4tm1Lky involves: 129/Sv * C57BL/6 MGI:3687996
cn3
 		Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5435903
cx4
 		Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+ 		involves: 129 * BALB/cJ * C57BL/6 MGI:5313999


Genotype
MGI:5313997
hm1
Allelic
Composition		 Il4tm1(CD2)Mmrs/Il4tm1(CD2)Mmrs
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes
decreased IgE level ( J:178986 )
• in mice infected with Nippostrongylus brasiliensis
decreased IgG1 level ( J:178986 )
• in an anti-NP response
decreased interleukin-4 secretion ( J:181313 )
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes

hematopoietic system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation compared with Il4tm1(CD2)Mmrs heterozygotes
decreased IgE level ( J:178986 )
• in mice infected with Nippostrongylus brasiliensis
decreased IgG1 level ( J:178986 )
• in an anti-NP response




Genotype
MGI:3687996
ht2
Allelic
Composition		 Il4tm1(CD2)Mmrs/Il4tm1Lky
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (46 available)
Il4tm1Lky mutation (3 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:113279 )
• mice are viable; dual-reporter mice were used for detailed profiling of Il4 mRNA and protein production in response to stimulation in culture and parasitic infection in vivo




Genotype
MGI:5435903
cn3
Allelic
Composition		 Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (985 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (29 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice exhibit reduced helminthes Nippostrongylus brasiliensis expulsion compared with control mice

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis




Genotype
MGI:5313999
cx4
Allelic
Composition		 Cigs2tm1.1Anse/Cigs2+
Il4tm1(CD2)Mmrs/Il4+
Genetic
Background		 involves: 129 * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cigs2tm1.1Anse mutation (0 available); any Cigs2 mutation (0 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:181313 )
N
• following intraperitoneal injection of ovalbumin, mice exhibit normal IgG2b response compared with Il4tm1(CD2)Mmrs heterozygotes
• T cells and basophils exhibit normal Il13 production
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased interleukin-4 secretion ( J:181313 )
• in Th2 polarized CD4+ T cells compared with Il4tm1(CD2)Mmrs heterozygotes
• in parathymic lymph node and lung-draining mediastinal node T cells from mice injected with ovalbumin
• in T cells and basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation

hematopoietic system
decreased basophil cell number ( J:181313 )
• reduced CD2+ basophils from mice sensitized and challenged with ovalbumin to induce allergic airway inflammation
decreased IgE level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes
decreased IgG1 level ( J:181313 )
• following intraperitoneal injection of ovalbumin as in Il4tm1(CD2)Mmrs homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory