All Phenotypes Vav1<tm2Tyb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vav1^tm2Tyb/Vav1^tm2Tyb	involves: 129S4/SvJae * 129S8/SvEv	MGI:3689307
hm2	Vav1^tm2Tyb/Vav1^tm2Tyb	involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd	MGI:3689308
cx3	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb	involves: 129S4/SvJae * 129S8/SvEv	MGI:3689310
cx4	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb Tg(TcrAND)53Hed/0	involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL	MGI:3689309

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-negative T cell number ( J:113270 )

• decreased compared to controls; however, this decrease is less than that in homozygous null mice

• significant decrease in the number of DN4 cells suggesting a partial block in development between the DN3 and DN4 stages

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• cell numbers in the spleen and lymph nodes are similar to controls

• slight but significant reduction in CD4+ cell numbers in the thymus, although not as large as in homozygous null mice

abnormal T cell physiology ( J:113270 )

• significant reduction in CD5 and CD2 expression, although not as much as in homozygous null mice

• reduced T cell receptor-induced calcium fluxes, although not as much as in homozygous null mice

decreased T cell proliferation ( J:113270 )

• reduced CD4+ cell proliferation in response to anti-CD3 alone or anti-CD3 plus anti-CD28; however proliferation is increased compared to homozygous null mice and proliferation of CD8+ cells is similar to controls

hematopoietic system

decreased double-negative T cell number ( J:113270 )

• decreased compared to controls; however, this decrease is less than that in homozygous null mice

• significant decrease in the number of DN4 cells suggesting a partial block in development between the DN3 and DN4 stages

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• slight but significant reduction in CD4+ cell numbers in the thymus, although not as large as in homozygous null mice

• cell numbers in the spleen and lymph nodes are similar to controls

abnormal T cell physiology ( J:113270 )

• significant reduction in CD5 and CD2 expression, although not as much as in homozygous null mice

• reduced T cell receptor-induced calcium fluxes, although not as much as in homozygous null mice

decreased T cell proliferation ( J:113270 )

cellular

decreased T cell proliferation ( J:113270 )

Allelic Composition	Vav1^tm2Tyb/Vav1^tm2Tyb
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv * C57BL/10 * C57BR/cd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal negative T cell selection ( J:113270 )

• deletion of CD4+ cells expressing Vbeta5, 11, and 12 is greater than in homozygous null mice but less than in wild-type mice, suggesting impaired negative selection

abnormal CD4-positive, alpha beta T cell morphology ( J:113270 )

hematopoietic system

abnormal negative T cell selection ( J:113270 )

• deletion of CD4+ cells expressing Vbeta5, 11, and 12 is greater than in homozygous null mice but less than in wild-type mice, suggesting impaired negative selection

abnormal CD4-positive, alpha beta T cell morphology ( J:113270 )

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested T cell differentiation ( J:113270 )

• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone

hematopoietic system

arrested T cell differentiation ( J:113270 )

• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb Tg(TcrAND)53Hed/0
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (123 available)
Tg(TcrAND)53Hed mutation (2 available)
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• reduced percentage of CD4+ cells compared to mice wild-type for Vav1

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• reduced percentage of CD4+ cells compared to mice wild-type for Vav1

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24