Analysis Tools
mortality/aging
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• viable at E9.5 but all die by E10.5
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embryo
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• vessels are present but fail to undergo extensive branching and are disorganized
• vessels appear narrower
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• slight at E9.5 and severe by E10.5
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• fails to develop normally
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• the allantoic mesoderm fails to invaginate into the chorionic trophoblast resulting in failure of labyrinth layer formation
• the interface between the chorionic/labyrinth trophoblast and the maternal blood space is almost linear with few fetal vessels detected
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• abnormally compact
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• fewer blood islands
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• significant decrease in the number of erythroid cells but numbers of erythroid progenitors appears similar to wild-type
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• the allantoic mesoderm fails to invaginate into the chorionic trophoblast resulting in failure of labyrinth layer formation
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hematopoietic system
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• significant decrease in the number of erythroid cells but numbers of erythroid progenitors appears similar to wild-type
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cardiovascular system
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• intersomitic vessels form but often fail to extend fully dorso-ventrally along the somites and are abnormally organized
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• fails to develop normally
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• the cranial vessels fail to expand into an organized network
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• the dorsal aorta is enlarged and appears disorganized both cranially and caudally
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• vessels are present but fail to undergo extensive branching and are disorganized
• vessels appear narrower
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• poorly developed trabeculae and sinusoids at E9.5
• at E9.5 the ventricular trabecular network is less complex and discontinuous
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growth/size/body
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• slight at E9.5 and severe by E10.5
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muscle
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• poorly developed trabeculae and sinusoids at E9.5
• at E9.5 the ventricular trabecular network is less complex and discontinuous
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