All Phenotypes Tfap2c<tm2Will> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tfap2c^tm2Will
targeted mutation 2, Trevor Williams
MGI:3687003

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tfap2a^tm2Will/Tfap2a⁺ Tfap2c^tm1Will/Tfap2c^tm2Will Tg(Zp3-cre)3Mrt/0	involves: 129S1/Sv * FVB/N	MGI:3687953
cn2	Tfap2c^tm1Will/Tfap2c^tm2Will Tg(Zp3-cre)3Mrt/0	involves: 129S1/Sv * FVB/N	MGI:3687951
cn3	Tfap2a^tm1Hsv/Tfap2a^tm2Will Tfap2c^tm1Will/Tfap2c^tm2Will Tg(Zp3-cre)3Mrt/0	involves: 129S1/Sv * FVB/N	MGI:3687952

Allelic Composition	Tfap2a^tm2Will/Tfap2a⁺ Tfap2c^tm1Will/Tfap2c^tm2Will Tg(Zp3-cre)3Mrt/0
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2a^tm2Will mutation (1 available); any Tfap2a mutation (39 available)
Tfap2c^tm1Will mutation (0 available); any Tfap2c mutation (28 available)
Tfap2c^tm2Will mutation (1 available); any Tfap2c mutation (28 available)
Tg(Zp3-cre)3Mrt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:113442 )

• embryos are smaller than wild-type, with morphology similar to published reports of Tcfap2c-null embryos

abnormal embryonic tissue morphology ( J:113442 )

• embryos are more disorganized than wild-type, with morphology similar to published report of Tcfap2c-null embryos

abnormal extraembryonic tissue morphology ( J:113442 )

• embryos are more disorganized than wild-type, with morphology similar to published report of Tcfap2c-null embryos

growth/size/body

decreased embryo size ( J:113442 )

• embryos are smaller than wild-type, with morphology similar to published reports of Tcfap2c-null embryos

Allelic Composition	Tfap2c^tm1Will/Tfap2c^tm2Will Tg(Zp3-cre)3Mrt/0
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2c^tm1Will mutation (0 available); any Tfap2c mutation (28 available)
Tfap2c^tm2Will mutation (1 available); any Tfap2c mutation (28 available)
Tg(Zp3-cre)3Mrt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:113442 )

N	• blastocyts derived from zygotes lacking both maternal and zygotic Tcfap2c contributions make it through preimplantation development

Allelic Composition	Tfap2a^tm1Hsv/Tfap2a^tm2Will Tfap2c^tm1Will/Tfap2c^tm2Will Tg(Zp3-cre)3Mrt/0
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2a^tm1Hsv mutation (1 available); any Tfap2a mutation (39 available)
Tfap2a^tm2Will mutation (1 available); any Tfap2a mutation (39 available)
Tfap2c^tm1Will mutation (0 available); any Tfap2c mutation (28 available)
Tfap2c^tm2Will mutation (1 available); any Tfap2c mutation (28 available)
Tg(Zp3-cre)3Mrt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:113442 )

• a significant reduction in number of double-null embryos (5.5% vs 25% expected) compared to 3 other possible genotypic combinations results in earlier lethality than loss of either allele alone (~E7.5)

embryo

embryo phenotype ( J:113442 )

• double-null embryos are found at ~expected frequencies (~25%) at E3.5; embryos are detected in both the morula (~75%) and blastocyst (~25%) stages, indicating that deficiency of both Tcfap2a and Tcfap2c does not affect the zygote prior to E3.5;

• other genotypic combinations are all found at similar frequencies (~25%) at E7.5, indicating that loss of any combination of 3 of 4 wild-type Tcfap2a and Tcfap2c alleles allows embryo survival to ~E7.5

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