Phenotypes associated with this allele

• Allele Symbol: Tg(HLA-DQA1,HLA-DQB1)70Myl
• Allele Name: transgene insertion 70, Myra A Lipes
• Allele ID: MGI:3687022
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl/0	NOD.Cg-H2-Ab1^b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl	MGI:3687027

Genotype
MGI:3687027

cx1

• Allelic Composition: H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru; Tg(HLA-DQA1,HLA-DQB1)70Myl/0
• Genetic Background: NOD.Cg-H2-Ab1^b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

myocardium necrosis ( J:88055 )

• associated with myocarditis with lymphocytic infiltrates

heart inflammation ( J:88055 )

• hearts show extensive mononuclear infiltrates in the atria; ventricles show focal infiltrates

myocarditis ( J:88055 )

• myocarditis development is transgene- and NOD-specific; the transgenics all exhibit myocarditis

digestive/alimentary system

salivary gland inflammation ( J:88055 )

• observed in transgenic and non-transgenic littermates with equal frequency

endocrine/exocrine glands

salivary gland inflammation ( J:88055 )

• observed in transgenic and non-transgenic littermates with equal frequency

insulitis ( J:88055 )

• transgenic mice show insulitis, but pancreatic beta cell damage is not sufficient to result in clinical diabetes

immune system

heart inflammation ( J:88055 )

• hearts show extensive mononuclear infiltrates in the atria; ventricles show focal infiltrates

myocarditis ( J:88055 )

• myocarditis development is transgene- and NOD-specific; the transgenics all exhibit myocarditis

salivary gland inflammation ( J:88055 )

• observed in transgenic and non-transgenic littermates with equal frequency

insulitis ( J:88055 )

• transgenic mice show insulitis, but pancreatic beta cell damage is not sufficient to result in clinical diabetes

increased autoantibody level ( J:88055 )

• transgenic mice line 73 show the highest prevalence and titers of cardiac tissue autoantibodies (16/18 mice are positive), while only 5/24 line 70 transgenics are positive and have lower antibody titers

muscle

myocardium necrosis ( J:88055 )

• associated with myocarditis with lymphocytic infiltrates