Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(TcraBDC12-4.1)10Jos transgene insertion 10, Joslin Diabetes Center MGI:3687036 |
||||||||||||||||||||||||||||
| Summary |
6 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice develop diabetes (blood glucose >250 ml/dl) more rapidly than transgenic Rag1-null, Ins2-sufficient mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:111874 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice are diabetic; diabetes assessed by blood glucose measures >250 mg/dl on two consectutive measurements
|
|
• diabetic mice have nearly complete destruction of insulin producing cells
|
|
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
|
|
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
|
|
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
|
|
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
|
|
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes
|
|
• mice develop spontaneous diabetes aged 4-32 weeks; diabetes develops only in mice with at least 1 copy of H-2g7 (incidence is 50% with homozygosity, 15% in heterozygotes); both sexes of transgenic mice are equally affected
|
|
• thymus weight is variable, with some being normal and others having very low weight
• transgene expression in Rag1-deficient mice increases thymus cellularity and thymus weight almost to levels seen in NOD controls
|
|
• mice have greater percentage of double-positive T cells (93%) in the thymus compared to other genotypes
|
|
• mice are lymphopenic compared to Rag1-sufficient transgenic mice and control NOD animals; number of lymphocytes in peripheral blood is lower than in transgenic Rag1-sufficient mice both in percentage of total white blood cell count and absolute lymphocyte count
|
|
• mice have lower percentage of single positive CD4+ T cells (3%) in the thymus compared to other genotypes
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:111874 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells
|
|
• 10-week-old diabetic mice show severe insulitis; disease is heterogeneous with some non-diabetic mice displaying it; infiltrate consists of CD4 cells, with an absence of CD8 T cells
|
|
• 15% of mice heterozygous for H2g7 develop diabetes, compared to 50% of homozygous mice or 0% of non-H2g7 mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:111874 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• 15% of mice heterozygous for the H2 alleles develop diabetes by 44 weeks
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| type 1 diabetes mellitus | DOID:9744 |
OMIM:222100 |
J:111874 | |
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• O% of mice homozygous for H2q develop diabetes
|
| N |
• mice do not develop insulitis
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected
|
|
• insulitis is observed in some mice at 44 weeks but nor insulin autoantibodies are detected
|
|
• transgenic Rag1-sufficient mice do not develop diabetes
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 11/12/2024 MGI 6.24 |
|
|
|
||
