Phenotypes associated with this allele

• Allele Symbol: Cxcr2^{tm1(IL8RB)Dktr}
• Allele Name: targeted mutation 1, Wim Dokter
• Allele ID: MGI:3687177
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcr2^tm1(IL8RB)Dktr/Cxcr2^tm1(IL8RB)Dktr	involves: 129S2/SvPas * C57BL/6	MGI:3687376

Genotype
MGI:3687376

hm1

• Allelic Composition: Cxcr2^{tm1(IL8RB)Dktr}/Cxcr2^{tm1(IL8RB)Dktr}
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased leukocyte cell number ( J:113489 )

• slight increase is detected in females

increased granulocyte number ( J:113489 )

• slight increases in absolute neutrophilic granulocyte and lymphocyte count in females are observed at 9 weeks

decreased spleen weight ( J:113489 )

• in females, a slight decrease in absolute spleen weight (~85 mg) is seen compared to wild-type (95 mg)

immune system

immune system phenotype ( J:113489 )

N • chemokine-induced calcium mobilization in neutrophils and neutrophil influx/myeloperoxidase activity into the peritoneum in response to thioglycollate injections are comparable to wild-type mice

increased leukocyte cell number ( J:113489 )

• slight increase is detected in females

increased granulocyte number ( J:113489 )

• slight increases in absolute neutrophilic granulocyte and lymphocyte count in females are observed at 9 weeks

decreased spleen weight ( J:113489 )

• in females, a slight decrease in absolute spleen weight (~85 mg) is seen compared to wild-type (95 mg)

liver/biliary system

small liver ( J:113489 )

renal/urinary system

decreased kidney weight ( J:113489 )

• kidney weight is slightly decreased in males

endocrine/exocrine glands

small adrenal glands ( J:113489 )

• adrenal gland weights are slightly decreased in females at 9 weeks